Evidence map›Paper›PMID 42012614›Full record

ArticleMagma (New York, N.Y.)2026

Cerebral blood flow and time of exchange measurements using multi-TE blood-brain barrier arterial spin labeling MRI in IDH mutational subgroups of gliomas.

Gülce Turhan, Ayse Irem Cetin, Beatriz E Padrela, Amnah Mahroo, Omer-Yasin Cur, Simon Konstandin, Daniel Christopher Hoinkiss, Nora-Josefin Breutigam, Henk J M M Mutsaerts, Ayca Ersen Danyeli and 7 more

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In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gülce TurhanInstitute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
Ayse Irem CetinInstitute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
Beatriz E PadrelaDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Amnah MahrooUniversity Health Network, Toronto, Ontario, Canada.
Omer-Yasin CurDepartment of Electrical and Electronics Engineering, Bogazici University, Istanbul, Turkey.
Simon KonstandinFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Daniel Christopher HoinkissFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Nora-Josefin BreutigamFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Henk J M M MutsaertsDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Ayca Ersen DanyeliDepartment of Pathology, Acibadem University, Istanbul, Turkey.
Koray OzdumanBrain Tumor Research Group, Acibadem University, Istanbul, Turkey.
Klaus EickelFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Vera C KeilDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Matthias GüntherFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Jan PetrDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Alp DincerBrain Tumor Research Group, Acibadem University, Istanbul, Turkey.
Esin Ozturk-IsikInstitute of Biomedical Engineering, Bogazici University, Istanbul, Turkey. esin.ozturk@bogazici.edu.tr.

Funding

HORIZON EUROPE European Research Council 825664Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 121N03
6 · The paper itself

Abstract

objectiveIsocitrate dehydrogenase (IDH) mutations are key prognostic factors in gliomas. IDH-wildtype (IDH-wt) glioblastomas are high-grade tumors, which often exhibit blood-brain barrier (BBB) breakdown. Blood-brain barrier arterial spin labeling (BBB-ASL) is a novel MRI technique that provides information on cerebral blood flow (CBF) and water exchange time (Tex) across the BBB. The aim of this study was to evaluate the feasibility of using BBB-ASL to measure CBF and Tex for distinguishing IDH mutational subgroups in gliomas, while accounting for region-specific T2 relaxation time variations.

methodsTwenty-five histopathologically confirmed gliomas (15 IDH-wt and 10 IDH-mutant (IDH-mut); mean age

resultsrTex_116ms maps showed significantly lower energy in IDH-wt tumors (

conclusionMulti-TE BBB-ASL provides noninvasive insight into perfusion and water exchange characteristics in gliomas, with T2 relaxation time assumptions strongly influencing CBF and Tex estimates.

Indexed as

Arterial spin labelingBlood–brain barrierCerebral blood flowGliomaIDH mutationTime of exchange

Identifiers

PMID42012614

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.