Evidence map›Paper›PMID 42012648›Full record

SynthesisExperimental brain research2026

Effects of exercise on α-synuclein in rodent models of Parkinson's disease: a systematic review and meta-analysis.

Bingxuan Xie, Emily Parker, Qianting Deng, Luodan Yang

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bingxuan XieLaboratory of Exercise and Neurobiology, College of Physical Education and Sport Science, South China Normal University, Guangzhou, 510006, GD, China.
Emily ParkerMedical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Qianting DengLaboratory of Exercise and Neurobiology, College of Physical Education and Sport Science, South China Normal University, Guangzhou, 510006, GD, China. 2022021048@m.scnu.edu.cn.
Luodan YangLaboratory of Exercise and Neurobiology, College of Physical Education and Sport Science, South China Normal University, Guangzhou, 510006, GD, China. luodanyang@m.scnu.edu.cn.

Funding

Guangzhou Scientific Research Grant SL2024A04J00578National Natural Science Foundation of China 32300959SCNU Training Program of Innovation for Undergraduates 202510574016Sigma Xi Committee on Grants in Aid of Research G20241001-11397
6 · The paper itself

Abstract

This study evaluated the effects of exercise on α-synuclein (α-syn) expression in preclinical models of Parkinson’s disease (PD), examining the impact of exercise protocol, animal age, model types, brain region, and α-syn species. A systematic search of PubMed, Web of Science, Embase, and Scopus was conducted for studies published up to August 10, 2025. Of 1,835 records, 22 provided data suitable for meta-analysis. Exercise significantly reduced α-syn levels in PD models (-1.40, [-1.83, -0.97]). Region-specific analyses showed significant reductions in the substantia nigra (-1.34, [-1.75, -0.93]), and striatum (-1.67, [-2.35, -0.98]). Exercise also showed differential effects across α-syn species, with the greatest reduction observed in phosphorylated α-syn (-2.46, [-3.60, -1.33]), followed by oligomeric (-1.91, [-2.73, -1.09]) and aggregated α-syn (-1.59, [-2.99, -0.19]). Overall, these findings suggest that exercise reduces α-syn burden in preclinical PD models and may exert neuroprotective effects.

Indexed as

alpha-SynucleinParkinson DiseasePhysical Conditioning, AnimalAnimalsDisease Models, AnimalSubstantia Nigraalpha-SynucleinAlpha-synucleinExerciseMeta-analysisParkinson’s diseaseSystematic review

Identifiers

PMID42012648

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.