Evidence map›Paper›PMID 42012866›Full record

ArticleMicrobiology (Reading, England)2026

The Omp85 family protein, TamA, exhibits characteristics of a suitable drug target against

Rachael Duodu, David J Boocock, Lesley Hoyles, Jack C Leo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachael DuoduAntimcrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
David J BoocockAntimcrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Lesley HoylesAntimcrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Jack C LeoAntimcrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outer membrane (OM) of Gram-negative bacteria is crucial for cell stability and virulence and acts as a permeability barrier. The biogenesis, assembly and regulation of proteins in the OM are, therefore, attractive areas of study that could lead to identifying novel drug targets. The translocation and assembly module (TAM), composed of TamA and TamB, facilitates the insertion of some

Indexed as

Bacterial Outer Membrane ProteinsPseudomonas aeruginosaAnimalsAnti-Bacterial AgentsGene Expression Regulation, BacterialGene Knockout TechniquesMothsProteomicsPseudomonas InfectionsVirulenceAnti-Bacterial AgentsBacterial Outer Membrane Proteinsouter membrane proteinsproteomicstranscriptomicstranslocation and assembly module

Identifiers

PMID42012866
PMCPMC13098762

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.