Evidence map›Paper›PMID 42012979›Full record

ArticleCell reports2026

The naked mole-rat microbiome is associated with healthy aging and social structure.

Ceylan Tanes, Naomi G Wilson, Megan Smith, Tanvi T Patel, Carter Merenstein, Frederic D Bushman, Kyle Bittinger, Rochelle Buffenstein

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ceylan TanesDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Naomi G WilsonDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Megan SmithDepartment of Biological Sciences, University of Illinois, Chicago, IL, USA.
Tanvi T PatelDepartment of Biological Sciences, University of Illinois, Chicago, IL, USA.
Carter MerensteinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Frederic D BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kyle BittingerDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: bittingerk@chop.edu.
Rochelle BuffensteinDepartment of Biological Sciences, University of Illinois, Chicago, IL, USA. Electronic address: rbuffen@uic.edu.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
The Oro-Respiratory-Gut Virome Axis Over Space and TimeU54AG089323 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, Ronald G Collman · 2025 to 2026
$12.8M
Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman · 2023 to 2026
$7.6M
Computational methods for discovery of disease-modulating microbial genesR01LM014503 · NLM · WISTAR INSTITUTE · PI Noam Auslander · 2024 to 2026
$1.2M
The Respiratory Microbiome in COVID-19: Associations with Severity, Risk Factors, and Host PathwaysF31HL170550 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MERENSTEIN, CARTER · 2023 to 2024
$97k
NHLBI NIH HHS F31 HL170550NIAID NIH HHS P30 AI045008NIAID NIH HHS U19 AI174998NIA NIH HHS U54 AG089323NLM NIH HHS R01 LM014503
6 · The paper itself

Abstract

The naked mole-rat (NMR), Heterocephalus glaber, is an unusual mammal that lives underground in eusocial colonies. NMRs show remarkable longevity and are resistant to cancer, neurodegeneration, and cardiovascular disease. The gut microbiome is known to modulate human health and disease; here, we investigate the microbiome of NMRs, comparing fecal samples from individuals over different social ranks and over a span of more than three decades. In contrast to a cohort of C57BL6/J mice, which showed extensive age-related changes, we found little difference in the microbiota of NMRs from different age cohorts. Only the archaea Methanomassiliicoccus intestinalis, which was present in the NMR gut but not the murine gut, showed an increased proportion with older age. Pregnant queens were found to have higher microbial diversity, potentially a consequence of their aggressive coprophagia. Overall, these findings provide a rich and dynamic picture of the NMR microbiome and starting points for future investigation.

Indexed as

agingarchaeacecumCP: microbiologyHeterocephalus glaberMethanomassiliicoccus intestinalismicrobiomenaked mole-ratpregnancy

Identifiers

PMID42012979
PMCPMC13366431

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.