Evidence map›Paper›PMID 42013968›Full record

ArticleAmerican heart journal2026

Validity of the International Classification of Diseases, Tenth Revision codes in diagnosing myocardial infarction subtypes.

Connor Suscha, Elaine Luterstein, Nhi Tong, Seán Murphy, Avanthi Raghavan, Yuxi Liu, Jason H Wasfy, Pradeep Natarajan, James L Januzzi, Cian P McCarthy

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In one paragraph

Article in American heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Connor SuschaHeart and Vascular Institute, Mass General Brigham, Boston, MA.
Elaine LutersteinDepartment of Medicine, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA.
Nhi TongSchool of Pharmacy, University of California, San Francisco, CA.
Seán MurphyHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA.
Avanthi RaghavanHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA.
Yuxi LiuHeart and Vascular Institute, Mass General Brigham, Boston, MA.
Jason H WasfyHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA.
Pradeep NatarajanHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.
James L JanuzziHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA; Baim Institute for Clinical Research, Boston, MA.
Cian P McCarthyHeart and Vascular Institute, Mass General Brigham, Boston, MA; Harvard Medical School, Boston, MA; Baim Institute for Clinical Research, Boston, MA. Electronic address: cmccarthy37@mgb.org.

Funding

Improving the Health Status of Individuals with Type 2 Myocardial InfarctionK23HL167659 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Cian Patrick McCarthy · 2023 to 2026
$786k
NHLBI NIH HHS K23 HL167659
6 · The paper itself

Abstract

backgroundInternational Classification of Diseases, Tenth Revision (ICD-10) codes are commonly used for identifying myocardial infarction (MI) in clinical research and increasingly used to capture events in clinical trials; however, their accuracy for distinguishing MI subtypes is uncertain.

methodsIn this secondary analysis of a single-center prospective cohort study, consecutive individuals who underwent highsensitivity cardiac troponin testing between October 2023 and February 2025 were adjudicated by physicians as either an MI subtype, myocardial injury, or non-elevated troponin. Clinician adjudicated diagnoses were compared to ICD-10 codes attributable to type 1 MI, type 2 MI, and type 3-5 MI.

resultsIn a study of 24,524 individuals undergoing troponin testing, type 1 MI ICD-10 codes showed moderate sensitivity (53%) but high specificity (99%), whereas the ICD-10 codes for type 2 MI and types 3-5 MI demonstrated extremely low sensitivities (3% and 0%, respectively) despite high sepificitiy (99%).

conclusionsThese data suggest the ICD-10 codes for each individual MI subtype have such low sensitivity that they may not reliably and accurately identify these MI subtypes in clinical research or in quality metrics and value-based programs.

Indexed as

International Classification of DiseasesMyocardial InfarctionAgedFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsSensitivity and SpecificityTroponinTroponin

Identifiers

PMID42013968
PMCPMC13179829

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.