Evidence map›Paper›PMID 42014157›Full record

Observational studyBMJ open2026

Hongkou Advanced Research on Metabolism and Obesity iNtervention studY (HARMONY): a protocol for a longitudinal cohort study.

Chuwen Lin, Weijiong Chen, Shuang Liu, Baige Cao, Yan Ge, Yan Li, Yuanyuan Liu, Tiantian Guo, Jinfang Xu, Congrong Wang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chuwen Lin *Department of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Weijiong Chen *Department of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Shuang LiuDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Baige CaoDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Yan GeDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Yan LiShanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-3749-7773
Yuanyuan LiuDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Tiantian GuoDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.
Jinfang XuDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Congrong WangDepartment of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China crwang@tongji.edu.cn.ORCID http://orcid.org/0000-0002-8645-1114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObesity is a global chronic metabolic disorder associated with significant comorbidities and healthcare burdens. Nutrient-stimulated hormone (NuSH)-based therapies have markedly advanced the pharmacological treatment for obesity. However, heterogeneity in treatment responses, high discontinuation rates, post-cessation weight regain and concerns regarding long-term safety still remain unresolved. To address these challenges, we initiated the Hongkou Advanced Research on Metabolism and Obesity iNtervention studY (HARMONY), a real-world, prospective observational cohort designed to comprehensively monitor the metabolic responses and clinical outcomes of adults with overweight or obesity undergoing various weight management interventions, with particular attention to the application of NuSH therapy. METHODS AND ANALYSIS: The HARMONY study is a prospective, observational cohort study to be conducted at Shanghai Fourth People's Hospital, Hongkou district, Shanghai, China. The study will enrol approximately 1500 overweight and obese participants over a 5-year period. Data collection will occur at baseline, week 4, week 12, week 24 and annually thereafter, including anthropometric measures, clinical evaluations, metabolic assessments and treatment outcomes. The primary endpoint is the percentage change in body weight at week 12 and week 24, while secondary endpoints include glucose metabolism, lipid profiles, liver and intrapancreatic fat deposition and safety outcomes such as adverse events. The cohort will be followed longitudinally to assess the long-term impact of weight management interventions. ETHICS AND DISSEMINATION: Ethical approval for the study has been granted by the Medical Ethics Committee of Shanghai Fourth People's Hospital (No. 2025036-001). Study findings will be disseminated through peer-reviewed publications and academic conferences, with reporting in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. TRIAL REGISTRATION NUMBER: ChiCTR2500113384.

Indexed as

ObesityOverweightAdultChinaFemaleHumansLongitudinal StudiesMaleProspective StudiesResearch DesignWeight LossObesityOverweightTreatment Outcome

Identifiers

PMID42014157
PMCPMC13110636

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.