ArticleACS synthetic biology2026
pCODE tRNA Expression Plasmids Compensate for Rare Codons in Recombinant Protein Production.
Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The molecular mechanisms that constrain recombinant protein production and the importance of synonymous codon usage have not been fully elucidated. Codon frequency varies between different organisms, and rare codons are often avoided in "codon-optimized" synthetic gene constructs. Overexpression of tRNA genes is an alternative strategy to compensate for suboptimal codon usage, but the consequences and limitations of this approach have not been widely studied. Here, we develop and characterize a versatile collection of pCODE plasmids for tRNA overexpression in
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