Evidence map›Paper›PMID 42014887›Full record

ArticleOncogene2026

Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma.

Yuchao Zhang, Xuesong Yang, Xixi Li, Chen Zheng, Xuechao Zeng, Junju Chen, Mingpu Gao, Long Cheng, Zhenyan Xu, Lanjie Chen and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuchao Zhang *Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xuesong Yang *Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xixi Li *Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chen Zheng *Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xuechao Zeng *Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Junju ChenDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Mingpu GaoDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Long ChengDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhenyan XuDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lanjie ChenDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yixin GaoDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jian ZhongDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Nunu HuangDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xuesong LiuDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.
Kejun HeDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. hekejun3@mail.sysu.edu.cn.ORCID http://orcid.org/0009-0002-2993-3763
Nu ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-2817-7065
Xujia WuDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuxj76@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-6904-0778

Funding

China Postdoctoral Science Foundation 2024M763806National Natural Science Foundation of China (National Science Foundation of China) 82192894National Natural Science Foundation of China (National Science Foundation of China) 82341007National Natural Science Foundation of China (National Science Foundation of China) 82372694National Natural Science Foundation of China (National Science Foundation of China) 82403655National Natural Science Foundation of China (National Science Foundation of China) 82472813National Natural Science Foundation of China (National Science Foundation of China) 82503269National Natural Science Foundation of China (National Science Foundation of China) 82573307
6 · The paper itself

Abstract

Dysregulation of transfer RNA (tRNA) modification and reprogramming of codon-biased translation are commonly associated with cancer initiation and progression. However, their roles in chemoresistance and tumor recurrence remain poorly understood, especially in glioblastoma (GBM). This study establishes the tRNA-modifying enzyme YrdC N

Indexed as

Brain NeoplasmsDrug Resistance, NeoplasmFatty Acid-Binding Protein 7GlioblastomaLipid DropletsAnimalsCell Line, TumorCodonGene Expression Regulation, NeoplasticHumansMiceProtein BiosynthesisRNA, TransferTemozolomideTumor Suppressor ProteinsXenograft Model Antitumor AssaysCodonFABP7 protein, humanFatty Acid-Binding Protein 7RNA, TransferTemozolomideTumor Suppressor Proteins

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.