ArticleBMC cancer2026
Prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) in patients with Leptomeningeal Metastasis (LM) from solid tumors.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundLeptomeningeal metastasis (LM) arising from solid tumors signifies a late-stage complication in the cancer trajectory, often portending a poor prognosis. The prognostic factors remain elusive. Prior research has established the Neutrophil-to-Lymphocyte Ratio (NLR) as an independent prognostic marker in various malignancies; however, its prognostic utility in LM patients remains underexplored. This study aims to investigate the prognostic significance of NLR at the time of LM diagnosis. PATIENTS AND
methodsWe conducted a retrospective analysis involving 490 diagnosed LM patients with solid tumor origins at Zhejiang Cancer Hospital. NLR was computed at the time of LM diagnosis. Kaplan-Meier curves and Cox proportional models were employed to examine the association between NLR and overall survival (OS).
resultsFollowing exclusions, the cohort comprised 384 patients. The median age was 55 years (interquartile range, IQR: 51-61.25), with a median OS was 6.45 months (IQR: 2.1–15.6) and a median NLR was 4.09 (IQR: 2.81–7.57). The median interval between LM diagnosis and NLR assessment was 1 day (IQR: 0–3). NLR proved effective in stratifying the prognosis of LM patients (HR = 1.02, 95% CI 1.01–1.04, p = 0.009). Stratifying patients based on the median NLR into low- and high-risk groups revealed that the high-risk group exhibited a 1.324-fold increased risk of death compared to the low-risk group (HR = 1.324, 95% CI 1.069–1.640, p = 0.010). Subgroup analysis indicated that NLR independently predicted prognosis specifically in the invasive breast cancer subgroup (p = 0.002).
conclusionNLR emerges as a simple and accessible prognostic indicator in newly diagnosed patients with leptomeningeal metastasis stemming from solid tumors.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.