Evidence map›Paper›PMID 42015111›Full record

ArticleBMC neurology2026

Markers of left atrial cardiopathy and cognitive function trajectories in adults aged ≥ 45 years without atrial fibrillation: a population-based study.

Zhe Li, Danielle Marion, Jessica Blair, Elsayed Z Soliman, David Gladstone, Hooman Kamel, David Birnie, Doug Manuel, Frederick W Unverzagt, Virginia Howard and 1 more

Abstract read
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In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Zhe LiUniversity of Ottawa Heart Institute, Ottawa, K1Y 4W7, Canada.
Danielle MarionUniversity of Ottawa Heart Institute, Ottawa, K1Y 4W7, Canada.
Jessica BlairThe University of Alabama at Birmingham, Alabama, AL, 35294, USA.
Elsayed Z SolimanDepartment of Medicine, Wake Forest School of Medicine, Epidemiological Cardiology Center, Section on Cardiovascular Medicine, Winston Salem, North Carolina, NC, 27101, USA.
David GladstoneSunnybrook Health Sciences Centre, Toronto, M4N 3M5, Canada.
Hooman KamelDepartment of Neurology, Weill Cornell Medicine, New York, NY, 10021, USA.
David BirnieUniversity of Ottawa Heart Institute, Ottawa, K1Y 4W7, Canada.
Doug ManuelDepartment of Medicine, University of Ottawa, Ottawa, K1N 6N5, Canada.
Frederick W UnverzagtSchool of Medicine, Indiana University, Indianapolis, IN, 47405, USA.
Virginia HowardThe University of Alabama at Birmingham, Alabama, AL, 35294, USA.
Jodi D EdwardsUniversity of Ottawa Heart Institute, Ottawa, K1Y 4W7, Canada. jedwards@ottawaheart.ca.

Funding

Canadian Institutes of Health Research Project Grant PJT 169192
6 · The paper itself

Abstract

introductionThe study aims to investigate associations between markers of atrial cardiopathy and cognitive function trajectories in adults without prior AF.

methodsThe study included 4,486 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Markers of atrial cardiopathy included atrial premature complexes and N-Terminal pro-Brain Natriuretic Peptide (NT pro-BNP). Cognitive status was measured using the Six-Item Screener (SIS). Cognitive status trajectories were identified using latent class growth models.

resultsThree unique cognitive trajectories over the 8-year follow-up were identified: 86.7% showed a normal and stable trajectory of SIS score, 7.6% showed a progressively decreasing trajectory, and 5.7% showed a dramatic decreasing trajectory. Age, black participants, and antidepression drugs were significantly associated with the “dramatic decrease” trajectory. Elevated NT pro-BNP was significantly associated with the “dramatic decrease” trajectory. DISCUSSION: Markers of left atrial cardiopathy may have implications for early diagnosis and prevention of cognitive impairment.

Indexed as

Atrial Premature ComplexesCognitionCognitive DysfunctionNatriuretic Peptide, BrainPeptide FragmentsAgedAtrial FibrillationBiomarkersFemaleHeart AtriaHumansMaleMiddle AgedBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Atrial cardiopathyAtrial fibrillationBiomarkersCognitive trajectory

Identifiers

PMID42015111
PMCPMC13235208

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.