Evidence map›Paper›PMID 42015251›Full record

ArticleJournal of nanobiotechnology2026

Bioengineered anti-EpCAM-guided exosome nanocarriers delivering Foxp3 agonist butyrate achieve tissue-specific immunomodulation in autoimmune Sjögren's syndrome.

Bailing Tian, Qiyu Li, Bohan Chang, Shan Zhao

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bailing Tian *Department of Rheumatology and Immunology, First Hospital of China Medical University, Shenyang, 110001, China.
Qiyu Li *Department of Cardiology, First Hospital of China Medical University, Shenyang, 110001, China.
Bohan ChangDepartment of Rheumatology and Immunology, First Hospital of China Medical University, Shenyang, 110001, China.
Shan ZhaoDepartment of Rheumatology and Immunology, First Hospital of China Medical University, Shenyang, 110001, China. zhaoshan1109@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Sjögren's syndrome (pSS) is characterized by salivary gland-centered immune dysregulation, in which an imbalanced T follicular helper (Tfh)/T follicular regulatory (Tfr) axis drives aberrant follicular responses and glandular dysfunction. In this study, we developed an engineered exosome-based therapeutic platform (Exo@But-αEpCAM) by combining CD4

Indexed as

ButyratesExosomesForkhead Transcription FactorsSjogren's SyndromeAnimalsDrug CarriersFemaleHumansImmunomodulationMiceSalivary GlandsButyratesDrug CarriersForkhead Transcription FactorsFOXP3 protein, humanExosome EngineeringFoxp3 AgonistPrimary Sjögren’s SyndromeT Follicular Helper /T Follicular Regulatory AxisTissue-Targeted Delivery

Identifiers

PMID42015251
PMCPMC13255498

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.