Evidence map›Paper›PMID 42015539›Full record

ReviewImmunoHorizons2026

The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity.

Shanel M Tsuda, Anna-Maria Globig

Abstract readReview
In one paragraph

Review in ImmunoHorizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ASPIRE to new horizons.ImmunoHorizons · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shanel M TsudaAllen Institute for Immunology, Seattle, WA, United States.
Anna-Maria GlobigAllen Institute for Immunology, Seattle, WA, United States.ORCID 0000-0002-5236-7459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerves are active regulators of immunity. Here, we review the current understanding of neuroimmune communication, focusing on how peripheral neurons instruct immune cell differentiation and function. We discuss mechanisms by which neurotransmitters, neuropeptides, and cytokines mediate reciprocal signaling between nerves and immune cells across infection, allergy, autoimmunity, and cancer. We introduce the concept of nerves as "state-setters" of immunity and summarize emerging therapeutic strategies that target neuroimmune pathways. Finally, we highlight current methodological challenges and outline priorities for mapping the peripheral neuroimmune connectome to accelerate clinical translation.

Indexed as

ConnectomeNeuroimmunomodulationPeripheral Nervous SystemAnimalsCytokinesHumansNeoplasmsNeuronsNeuropeptidesSignal TransductionCytokinesNeuropeptidescancerinfectionneuroimmunology

Identifiers

PMID42015539
PMCPMC13099405

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.