ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Inhibition of ferroptosis by geniposide via activation of the SIRT3 signaling pathway to alleviate inflammatory injury in endothelial cells].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo study the effect and mechanism of geniposide (GE) on lipopolysaccharide (LPS)-induced inflammatory injury in human coronary artery endothelial cells (HCAECs).
methodsHCAECs were randomly assigned to four groups: control (no treatment); model (LPS 20 ng/mL for 24 hours); GE (GE 30 μg/mL pretreatment for 12 hours, followed by LPS 20 ng/mL for 24 hours); and SIRT3 inhibitor (GE 40 μg/mL plus the SIRT3-specific inhibitor 3-TYP pretreatment for 12 hours, followed by LPS 20 ng/mL for 24 hours). Cell viability was assessed by CCK-8 assay. Lactate dehydrogenase (LDH) activity in culture medium and intracellular malondialdehyde (MDA), glutathione (GSH), and ferrous ion (Fe
resultsCompared with the control group, the model group showed decreased cell viability, GSH content, SIRT3 immunofluorescence intensity, and GPX4, SLC7A11, and SIRT3 protein expression (
conclusionsGeniposide alleviates LPS-induced inflammatory injury in HCAECs, and the mechanism may involve inhibition of ferroptosis and activation of SIRT3 signaling.
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