Evidence map›Paper›PMID 42015787›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Candidate biomarker identification for blood stasis syndrome among coronary artery disease patients using the Olink proteomics platform.

L I Hongzheng, Lin Guosheng, Peng Yuxuan, Churov Alexey Viktorovich, Yang Wenwen, Wang Jie, L U Jieming, Liao Feifei, Y U Ruotong, Wei Yue and 7 more

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

L I HongzhengPostdoctoral Research Center,Guang'an Men Hospital, China Academy of Chinese Medical Sciences,Beijing100053,China.
Lin GuoshengAcademy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou350122,China.
Peng YuxuanNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
Churov Alexey ViktorovichInstitute of General Pathology and Pathophysiology,Pirogov Russian National Research Medical University,Moscow125315,Russia.
Yang WenwenDepartment of Cardiology,Shaanxi Provincial Hospital of Chinese Medicine,Xi'an710003,China.
Wang JieNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
L U JiemingNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
Liao FeifeiAcademy of Chinese Medicine,Beijing University of Chinese Medicine,Beijing100029,China.
Y U RuotongNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
Wei YueNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
Zhao ZhiruNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
L U AimeiAcademy of Chinese Medicine,Beijing University of Chinese Medicine,Beijing100029,China.
L I PengDepartment of Cardiology I,TCM Hospital Affiliated to Xinjiang Medical University,Urumqi830000,China.
Shen AlingAcademy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou350122,China.
Long LinziNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
Q U HuaNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.
F U ChanggengNational Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing100091,China.

Funding

Comprehensive Investigation into Diagnostic Criteria and a Risk Prediction Model for Coronary Heart Disease with "Dryness-Blood Stasis Complex" Syndrome in Xinjiang 2022E02114Formulation of International Diagnostic Criteria for Blood Stasis Syndrome in Coronary Heart Disease and Screening of Specific Protein Biomarkers CMC2022010Screening of Inflammatory Biomarkers and Analysis of Perivascular Adipose Tissue Characteristics in Patients with Blood Stasis Syndrome due to Coronary Heart Disease GWJJMB202510021048
6 · The paper itself

Abstract

objectiveTo identify candidate biomarkers of blood stasis syndrome (BSS) associated with coronary artery disease (CAD) and explore the underlying inflammatory mechanisms.

methodsUsing the Olink Target 96 Inflammation panel, we identified plasma proteins in a group of 88 patients comprised of healthy controls (HCs), those with CAD and BSS (CAD-BSS), those with CAD without BSS (CAD-non-BSS), and those with BSS without CAD (non-CAD-BSS) (

resultsPatients with CAD had 31/92 upregulated and 4/92 downregulated proteins compared with those without. Chemokine (C-C motif) ligand 11 (CCL11), CUB domain-containing protein 1, hepatocyte growth factor, sirtuin 2 (SIRT2), eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), CCL25, and tumor necrosis factor (TNF) showed the strongest upregulation (all

conclusionsResults suggest that the inflammatory response and mechanistic target of rapamycin signaling pathway participate in CAD and BSS development, and that SIRT2 and 4E-BP1 are prospective protein biomarkers for patients with CAD and BSS.

Indexed as

BiomarkersCoronary Artery DiseaseProteomicsAdultAgedBlood ProteinsFemaleHumansMaleMiddle AgedBiomarkersBlood Proteinsblood stasis syndromecoronary artery diseaseeukaryotic translation initiation factor 4E-binding protein 1hepatocyte growth factor, sirtuin 2inflammationOlink platform

Identifiers

PMID42015787
PMCPMC13077107

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.