ArticleJournal of asthma and allergy2026
Standardizing a Four-Marker Basophil Activation Test: Influence of Storage Time, Temperature, and IgE Levels.
Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
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Abstract
Background: Allergic diseases affect 25% of the global population, yet current diagnostics like specific IgE (sIgE) and skin prick tests lack specificity. The basophil activation test (BAT) offers high specificity but requires methodological standardization. Objective: This study develops gating strategies and pre-analytical storage conditions to develop an analytically validated BAT protocol for Methods: Seventy-nine adults (Df-sensitized and controls) were enrolled. Basophil activation was assessed by CD63 expression following Results: The three-marker gating strategy (CD123 Conclusion: This study demonstrates that a three-marker gating strategy within a four-color BAT panel reduces costs while maintaining analytical equivalence to a four-marker gating reference. Stimulus-specific storage patterns support flexible processing for research applications, and BAT outcomes provide complementary functional information beyond IgE levels. Clinical utility requires prospective validation.
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