Evidence map›Paper›PMID 42016624›Full record

ArticleClinical case reports2026

Recurrent Cytopathic Effects and Prolonged Viral Shedding in an Immunocompromised Patient With Malignant Lymphoma Treated With Rituximab and Bendamustine: A Case of Coronavirus Disease 2019 Relapse.

Takahisa Ohira, Taku Ogawa, Tomoko Tanaka, Shoichi Sakaguchi, Youichi Suzuki, Hong Wu, Tomoyuki Yamada, Yuriko Shibata, Kazuki Iwaki, Ayana Okazaki and 2 more

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takahisa OhiraInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Taku OgawaInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.ORCID https://orcid.org/0000-0003-1569-4642
Tomoko TanakaInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Shoichi SakaguchiDepartment of Microbiology and Infection Control, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Youichi SuzukiDepartment of Microbiology and Infection Control, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Hong WuDepartment of Microbiology and Infection Control, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Tomoyuki YamadaInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Yuriko ShibataInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Kazuki IwakiDepartment of Internal Medicine I Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Ayana OkazakiDivision of Rheumatology, Department of Internal Medicine (IV) Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Akira UkimuraInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.
Takashi NakanoInfection Control Center Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 79-year-old woman with malignant lymphoma initially recovered from mild coronavirus disease 2019 (COVID-19), but later developed pneumonia. Despite continuous PCR positivity, cytopathic effect (CPE) temporarily became negative before re-emerging with clinical deterioration. This case shows that PCR results alone cannot reliably determine viral infectivity, and once-negative CPE can become positive again.

Indexed as

COVID‐19cytopathic effectimmunocompromisedmalignant lymphomarelapse

Identifiers

PMID42016624
PMCPMC13093559

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.