ArticleInternational journal of genomics2026
Causal Effects of Atrial Fibrillation and Warfarin Use on Osteoporosis Risk: A Two-Sample Mendelian Randomization Analysis.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Causal Effects of Atrial Fibrillation and Warfarin Use on Osteoporosis Risk: A Two-Sample Mendelian Randomization Analysis.International journal of genomics · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A number of observational studies have previously reported an association between atrial fibrillation (AF), long-term warfarin therapy, and an increased risk of osteoporosis (OP). The proposed mechanisms behind this association involve chronic inflammation or vitamin K-dependent bone metabolism. However, the presence of confounding factors and methodological limitations precludes the drawing of causal conclusions. The present Mendelian randomisation (MR) study investigates the existence of genetic evidence for causal links between AF, warfarin use and OP development. Methods: The two-sample MR was performed using summary statistics from European-ancestry genome-wide association studies. Genetic instruments for AF (111 independent SNPs) and warfarin use (9 SNPs) were selected at stringent significance thresholds ( Results: IVW analysis showed no causal association between genetic predisposition to AF and OP risk (OR = 1.0006, 95% CI 0.9998-1.0014, Conclusions: This study, informed by genetic research, challenges established causal relationships between AF, warfarin use and the risk of OP. The observed clinical associations may be attributable to residual confounding or comorbidities present in ageing populations, rather than direct pharmacological effects. These findings provide a scientific basis for the clinical prioritisation of the management of thromboembolic risk over speculative concerns regarding bone health in the treatment of AF.
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Registered trials
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