ArticleNanotechnology, science and applications2026
Sacha Inchi Oil-Based Nanostructured Lipid Carriers for Curcumin Delivery: Development and Physicochemical Characterization.
Article in Nanotechnology, science and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Parenteral Berberine vs Cisplatin- Loaded Lipid Nanoparticles - Development, Characterisation, Comparative Safety Profiling and Cytotoxicity in Cholangiocarcinoma Cell Models.Nanotechnology, science and applications · 2026Article
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6 authors.
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Abstract
Background and Objective: Curcumin exhibits potent antioxidant activity beneficial for the prevention of various degenerative diseases; however, its highly lipophilic nature and susceptibility to degradation limit its solubility and physicochemical stability. To address these limitations, curcumin was formulated into nanostructured lipid carriers (NLCs), a lipid-based colloidal delivery system composed of solid and liquid lipids stabilized by surfactants. In this study, sacha inchi oil, a natural oil rich in omega-3 and other unsaturated fatty acids, was investigated as a novel liquid lipid component to improve lipid matrix structure and drug accommodation. Methods: Curcumin-loaded NLCs were prepared using the hot homogenization method followed by probe sonication. Curcumin served as the active compound, while solid lipids (oleum cacao, glyceryl behenate (Compritol Results: Physicochemical analyses confirmed successful incorporation of curcumin into the lipid matrix without undesirable interactions. Among the tested formulations, CaTS2 (oleum cacao 4.5%, sacha inchi oil 1%, Tween 80 12.5%, Span 80 1%, and curcumin 0.1%) demonstrated the most favorable characteristics, with a particle size of 95.50 ± 0.87 nm, PDI of 0.119 ± 0.157, and ZP of -22.30 ± 0.98 mV. Entrapment efficiency reached 97.24% and morphological analysis showed predominantly spherical particles. In vitro release exhibited a biphasic pattern, consisting of an initial burst followed by sustained release up to 480 min. Kinetic modeling revealed that CaTS2 followed the Korsmeyer-Peppas model ( Conclusion: Sacha inchi oil-based nanostructured lipid carriers were successfully developed and demonstrated favorable physicochemical characteristics, supporting their potential as a stable delivery system for curcumin.
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