Evidence map›Paper›PMID 42017361›Full record

ArticleEpilepsia2026

A consensus roadmap for post-traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials.

Elisa R Zanier, Ilaria Lisi, Elaine K O'Loughlin, Federico Moro, Edilberto Amorim, David L Brody, Daniel J Correa, Dominique Duncan, Pavel Klein, Firas H Kobeissy and 9 more

Abstract readConsensus Statement
In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elisa R ZanierDepartment of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0002-3011-8718
Ilaria LisiDepartment of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0002-4699-4341
Elaine K O'LoughlinCURE Epilepsy, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-4270-9902
Federico MoroDepartment of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0002-2682-5583
Edilberto AmorimDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-6972-5622
David L BrodyDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-4864-3262
Daniel J CorreaComprehensive Epilepsy Management Center, Saul R. Korey Department of Neurology, Montefiore Einstein, Bronx, NY and Office for Community Engagement and Outreach, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID https://orcid.org/0000-0002-6490-9331
Dominique DuncanDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-6154-9262
Pavel KleinMid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-7244-3722
Firas H KobeissyCenter for Neurotrauma, MultiOmics and Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-5008-6944
Wolfgang LöscherDepartment of Experimental Otology, ENT Clinics, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-9648-8973
Edward J NeedhamDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-7042-7462
Asla PitkänenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-8163-5416
Mary Jo PughDepartment of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah; Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS) VA, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-4196-7763
Jack SomersPerson Living with PTE, Santa Monica, California, USA.
Annamaria VezzaniDepartment of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0003-0573-6175
Amy K WagnerDepartment of Physical Medicine & Rehabilitation, Department of Neuroscience, Safar Center for Resuscitation Research, Clinical and Translational Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3245-6523
Laura S LubbersCURE Epilepsy, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-1645-9356
International Conference on PTE Attendees

Funding

The Roadmap from Preclinical Models to Interventional Trials for PTER13NS134285 · NINDS · CITIZENS UNITED FOR RESEARCH IN EPILEPSY · PI HARTE, LAUREN, ZANIER, ELISA R · 2023 to 2023
$25k
NINDS NIH HHS R13 NS134285
6 · The paper itself

Abstract

Understanding the mechanisms underlying post-traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade. However, to date, preclinical and clinical researchers with expertise in these areas have not formally convened to discuss ways to move the field forward. To enable communication and collaboration, scientific experts as well as individuals with lived experience of PTE were gathered during the inaugural International Conference on Post-Traumatic Epilepsy (IC-PTE) held in Milan, Italy, in May 2024, to identify challenges and solutions for advancing research toward clinical trials. The IC-PTE focused on potential therapeutic approaches, clinical and preclinical biomarker discovery, and methods to predict PTE risk early following TBI, which is an important consideration in clinical trial design. In addition, conference attendees discussed animal model development with a focus on clinically relevant translational endpoints and data harmonization and sharing across the PTE research community. This article identifies recommendations for the field and outlines a strategic roadmap for interventional trials targeting PTE.

Indexed as

Epilepsy, Post-TraumaticAnimalsBiomarkersBrain Injuries, TraumaticClinical Trials as TopicDisease Models, AnimalHumansBiomarkersbiomarkersclinical trialslived experiencenew therapiespost‐traumatic epilepsy

Identifiers

PMID42017361
PMCPMC13361008

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.