Evidence map›Paper›PMID 42017793›Full record

ArticleeLife2026

Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response.

Shiqiang Xu, Alix Buridant, Thibault Hirsch, Céline Duhamel, Benjamin Ledoux, Massiullah Shafaq-Zadah, Estelle Dransart, Louise Thines, Ludger Johannes, Pierre Van der Bruggen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shiqiang XuUNamur, Namur Research Institute in Life Sciences, Research Unit in Cell Biology, Namur, Belgium.ORCID https://orcid.org/0000-0002-0696-499X
Alix BuridantUNamur, Namur Research Institute in Life Sciences, Research Unit in Cell Biology, Namur, Belgium.ORCID https://orcid.org/0009-0000-4549-0013
Thibault HirschUCLouvain, de Duve Institute, Bruxelles, Belgium.ORCID https://orcid.org/0000-0002-4448-1948
Céline DuhamelUCLouvain, de Duve Institute, Bruxelles, Belgium.
Benjamin LedouxUNamur, Morph-Im Platform, Namur, Belgium.ORCID https://orcid.org/0009-0004-0336-6478
Massiullah Shafaq-ZadahInstitut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID https://orcid.org/0000-0002-7582-8131
Estelle DransartInstitut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID https://orcid.org/0000-0003-2547-6825
Louise ThinesUNamur, Namur Research Institute in Life Sciences, Research Unit in Cell Biology, Namur, Belgium.ORCID https://orcid.org/0009-0003-4208-4580
Ludger JohannesInstitut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID https://orcid.org/0000-0002-2168-0004
Pierre Van der BruggenUCLouvain, de Duve Institute, Bruxelles, Belgium.ORCID https://orcid.org/0000-0002-3910-4101
Pierre MorsommeUCLouvain, Louvain Institute of Biomolecular Science and Technology, Group of Molecular Physiology, Louvain-la-Neuve, Belgium.ORCID https://orcid.org/0000-0001-7780-7230
Henri-François RenardUNamur, Namur Research Institute in Life Sciences, Research Unit in Cell Biology, Namur, Belgium.ORCID https://orcid.org/0000-0002-2406-2519

Funding

Agence Nationale de la Recherche ANR-20-CE15-0009-01Agence Nationale de la Recherche ANR-22-CE11-0030-03European Research Council 101062030Fondation Francqui - Stichting Start-Up GrantFondation pour la Recherche Médicale EQU202103012926Fonds De La Recherche Scientifique - FNRS CDR-J.0176.24Fonds De La Recherche Scientifique - FNRS J.0127.23Fonds De La Recherche Scientifique - FNRS MIS-F.4540.21Fonds De La Recherche Scientifique - FNRS Postdoc FellowshipFonds De La Recherche Scientifique - FNRS T.0163.21Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture PhD FellowshipH2020 Marie Skłodowska-Curie Actions 101151524Mizutani Foundation for Glycoscience 200014UNamur and UCLouvain, Fonds Spéciaux de Recherche PhD Fellowship
6 · The paper itself

Abstract

Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) contributes to the internalization of immunoglobulin-like proteins, including key immune synapse components. Here, we identify ICAM1 as a novel EndoA3-dependent cargo, alongside ALCAM. We demonstrate that both proteins subsequently follow retromer-dependent retrograde transport to the

Indexed as

CD8-Positive T-LymphocytesClathrinEndocytosisImmunological SynapsesNeoplasmsCell Line, TumorHumansIntercellular Adhesion Molecule-1ClathrinICAM1 protein, humanIntercellular Adhesion Molecule-1cancer cellCD8 T cellcell biologyendocytosishumanimmune synapseimmunoglobulinimmunologyinflammationretrograde transport

Identifiers

PMID42017793
PMCPMC13102394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.