ArticleBiogerontology2026
Shenrong Guben Huanshao Pill enhanced stress resistance and extended the lifespan of Caenorhabditis elegans by activating the oxidative stress system via the DAF-16/FOXO signaling pathway.
Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
SRGBHSP is a classic traditional Chinese medicinal. Modern studies found that SRGBHSP had antioxidant, anti-inflammatory and constitution-strengthening pharmacological effects. Oxidative stress is a major factor that can cause an organism to age. Therefore, we proposed that SRGBHSP has an aging modulatory effect by its antioxidant properties. In the present study, we used a C. elegans model to explore the aging modulatory activity of the extract from SRGBHSP. Aging modulatory effects of SRGBHSP were determined by lifespan assays under normal and extreme conditions, as well as assays for body bending frequency and pharyngeal pumping rate. In vivo antioxidant activity of SRGBHSP was estimated through ROS, MDA levels and the activities of antioxidant enzymes. The mechanisms of aging modulatory effects of SRGBHSP were further investigated via qRT-PCR, nuclear translocation assay, transcriptomics and metabolomics analysis. SRGBHSP extends the lifespan of C. elegans and reduces the accumulation of oxidative metabolites. SRGBHSP upregulated the transcription of daf-16, promoted the nuclear translocation of DAF-16 and increased the transcription of downstream genes sod-3 and gst-4. KEGG enrichment analysis of the transcriptome identified the peroxisome pathway and the classical DAF-16/FOXO-dependent IIS longevity pathway. Metabolomics indicates that SRGBHSP primarily exerts its function by affecting the vitamin B6 metabolic pathway. The results of this study showed that SRGBHSP increased the activity of antioxidant enzyme in C. elegans and reduced the products of oxidative metabolism to prevent oxidative stress. Its aging modulatory effect is mainly produced through the activation of DAF-16/FOXO-dependent IIS signaling pathway and vitamin B6 metabolic pathway.
Indexed as
Identifiers
42018048What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.