Evidence map›Paper›PMID 42018143›Full record

ArticleJACC. Basic to translational science2026

RIG-I-Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction.

Nandadeva Lokugamage, Allison Wyrick, Subhadip Choudhuri, Maher Raja, Imran H Chowdhury, Siddhartha De, Upendra Marathi, Nisha Jain Garg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nandadeva LokugamageDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Allison WyrickDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Subhadip ChoudhuriDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Maher RajaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Imran H ChowdhuryDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Siddhartha De7 Hills Pharma Inc., Houston, Texas, USA.
Upendra Marathi7 Hills Pharma Inc., Houston, Texas, USA.
Nisha Jain GargDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA. Electronic address: nigarg@utmb.edu.

Funding

Oxidative Response Networks in Chagasic CardiomyopathyR01AI136031 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Nisha Jain Garg · 2017 to 2026
$3.6M
Integrin activator-adjuvanted DNA vaccine against Trypanosoma cruzi infectionR44AI172437 · NIAID · 7 HILLS PHARMA, LLC · PI DE, SIDDHARTHA, GARG, NISHA JAIN · 2022 to 2024
$3.0M
NIAID NIH HHS R01 AI136031NIAID NIH HHS R44 AI172437
6 · The paper itself

Abstract

BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi. Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.

Indexed as

antibody and T cell responsebicistronic immunogenChagas diseaseheart functionTrypanosoma cruzi

Identifiers

PMID42018143
PMCPMC13031056

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.