Evidence map›Paper›PMID 42018263›Full record

SynthesisSleep & breathing = Schlaf & Atmung2026

Elevated uric acid in patients with obstructive sleep apnea increases the risk of stroke: A systematic review and meta-analysis combined with a retrospective cohort study.

Hui Xu, Jun Yang, Xuanxuan Li, Junqian Yang, Zihan Yao, Xinyuan Zhang, Bo Xie, Yijing Guo, Xiaoli Li

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui XuDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China.ORCID http://orcid.org/0009-0001-4955-0017
Jun YangLishui People's Hospital, Nanjing, Jiangsu, China.
Xuanxuan LiDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China.
Junqian YangSchool of Medicine, Southeast University, Nanjing, China.
Zihan YaoSchool of Medicine, Southeast University, Nanjing, China.
Xinyuan ZhangSchool of Medicine, Southeast University, Nanjing, China.
Bo XieInstitute of Health and Socicty, School of Medicine, Southeast University, Nanjing, China. Boxxie80@163.com.
Yijing GuoDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China. guoyijingseu@126.com.
Xiaoli LiDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China. lixiaolifirst@163.com.ORCID http://orcid.org/0000-0002-8966-9792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) is linked to stroke events, but the role of serum uric acid (UA) in stroke remains controversial and analyses of changes in UA and stroke are limited. Furthermore, their combined effect on stroke risk remains unclear. This study investigated the relationship between OSA severity and serum UA, and whether elevated UA increases stroke risk in OSA patients.

methodsA systematic search of PubMed and Web of Science (up to Dec 2024) identified relevant studies for a meta-analysis. Concurrently, a retrospective analysis was conducted on OSA patients (2020–2024) from Zhongda Hospital affiliated with Southeast University along with healthy controls. Patients and controls were stratified by apnea-hypopnea index (AHI) and UA levels. Multivariable logistic regression identified stroke risk factors.

resultsThe meta-analysis showed OSA severity was positively correlated with UA levels (p < 0.001). The retrospective analysis showed each unit increase in UA was associated with a 1% higher stroke risk (adjusted OR: 1.01; p < 0.001). Hyperuricemia increased the odds of stroke 2.88-fold (adjusted OR: 2.88; p = 0.020).

conclusionsOSA severity is associated with hyperuricemia, and elevated UA independently predicts stroke risk in OSA patients. Monitoring UA may help identify high-risk individuals for intervention.

Indexed as

HyperuricemiaSleep Apnea, ObstructiveStrokeUric AcidHumansMiddle AgedRetrospective StudiesRisk FactorsUric AcidHyperuricemiaMeta-analysisObstructive sleep apneaRetrospective studySleep disordersStroke

Identifiers

PMID42018263

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.