Evidence map›Paper›PMID 42018634›Full record

ArticleScience advances2026

High altitude-mediated immune remodeling accelerates aging.

Yu Xiao, Yongfu Li, Yaqi Mao, Zichong Jin, Mengjie Sun, Xiangyang Wang, Gan Zhao, Yihong Song, Jing Li, Zhiying Zhang and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Yu XiaoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0003-3107-411X
Yongfu LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0003-3141-3206
Yaqi MaoKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.ORCID 0009-0004-4439-1426
Zichong JinKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.ORCID 0009-0003-7000-9289
Mengjie SunThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Xiangyang WangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0005-3827-0414
Gan ZhaoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0002-1386-7223
Yihong SongThe Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0005-3983-8753
Jing LiKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.ORCID 0000-0002-0969-6118
Zhiying ZhangKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.
Lijun LiuKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.ORCID 0009-0006-6972-798X
Siwei FengKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China.ORCID 0000-0003-4788-3202
Mingzheng LiuThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0000-5139-1038
Ziheng ChenThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0002-1575-4844
Xinmei GuoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Rui YuThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Hongju LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Caifeng YangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Changfen LuoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Jiahong LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0000-0765-8954
Zhifang ZhaoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Juan ZhangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Lu CaiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Haiyang MaThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0008-3041-1843
Shuqing LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Shangshi LiKey Laboratory of High Altitude and Frigidzone Medical Support, General Hospital of Xizang Military Area Command, Xizang 850000, China.
Fengye XuSmartgenomics Technology Institute, Tianjin 300000, China.ORCID 0009-0001-4668-8344
Guangwei XinThe Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0003-0718-8296
Qing JiangThe Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-7572-3436
Fen HuangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0001-9147-2537
Longli KangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0001-6881-3241
Chuanmao ZhangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0003-1359-6475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High altitude-associated pathophysiological processes may potentially accelerate aging trajectory, while evidence remains limited. We present immune landscape characterization in human populations residing at 3656-meter (Lhasa) and 5070-meter (Tuiwacun) elevations on the Qinghai-Tibet Plateau, complemented by multiorgan single-cell RNA sequencing and spatially enhanced resolution omics sequencing (Stereo-seq) of mice under simulated 5000-meter hypoxic conditions. Comparative analysis revealed significantly elevated neutrophil proportions in high-altitude population (HAP) cohorts relative to low-altitude population cohorts. Notably, aging-associated immune cells (AICs) including exhausted T cells, age-associated B cells, and high-aging-score immune cells showed marked enrichment in HAP cohorts, a pattern conserved in mouse models. Stereo-seq analyses further identified coordinated niche interactions between AICs and aging-related intestinal epithelial cells, suggesting accelerated gut aging trajectories. Our work establishes the multiomics framework for high-altitude immune remodeling while providing mechanistic insights into high altitude-associated pathophysiological processes.

Indexed as

AgingAltitudeAnimalsB-LymphocytesHumansHypoxiaMaleMiceMultiomicsNeutrophilsT-Cell ExhaustionT-Lymphocytes

Identifiers

PMID42018634
PMCPMC13101872

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.