Evidence map›Paper›PMID 42018740›Full record

ArticleThe Laryngoscope2026

Meniere's Disease and Migraine: Effect of Migraine Medications on Symptoms of Meniere's Disease.

Khushi Bhatt, Yueqi Ren, Charlotte Chan, Marianne Rara, Hamid R Djalilian, Mehdi Abouzari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Khushi BhattDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Yueqi RenDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Charlotte ChanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Marianne RaraDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0003-2270-5207
Mehdi AbouzariDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0002-3585-698X

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
NCATS NIH HHS TL1 TR001415NCATS NIH HHS TL1TR001415NCATS NIH HHS UL1 TR001414NCATS NIH HHS UM1 TR004927NCRR NIH HHS TL1TR001415
6 · The paper itself

Abstract

objectivesTo observe the incidence of Meniere's disease (MD) and MD-related symptoms (i.e., aural fullness, tinnitus, hearing loss, and vertigo) between (a) non-migraine and migraine patients and (b) migraine untreated and migraine treated patients within the TriNetX database.

methodsWe conducted a retrospective cohort study of (a) non-migraine and migraine patients and (b) migraine treated and untreated patients within the TriNetX database from 2013 till 2025. Patients underwent propensity score matching for sex, age, race, and known lifestyle/disease confounders for MD. Incidence of MD and MD-related symptoms were evaluated 5 years post index date and beyond 5 years post index date.

resultsMigraine patients demonstrated a greater incidence of MD and MD-related symptoms 5 years and more than 5 years post index date. Amongst migraine patients, those not receiving treatment demonstrated a lesser predilection (risk ratio [RR] = 0.43, 95% CI: 0.28-0.66) of developing MD than patients receiving treatment. There was no significant difference in the incidence of hearing loss or aural fullness between migraine untreated and treated subgroups. Migraine patients not receiving treatment had an increased risk of experiencing tinnitus (RR = 1.11, 95% CI: 1.03-1.19).

conclusionsThere exists a connection between migraine and MD. Migraine patients receiving migraine treatment are statistically significantly more likely to develop MD compared to non-migraine patients. These results support the findings of preceding studies that have demonstrated a pathophysiological link between migraine and vestibulocochlear dysfunction. LEVEL OF EVIDENCE: 3:

Indexed as

Meniere DiseaseMigraine DisordersAdultFemaleHearing LossHumansIncidenceMaleMiddle AgedRetrospective StudiesTinnitusVertigoaural fullnesshearing lossMeniere's diseasemigrainetinnitusvertigo

Identifiers

PMID42018740
PMCPMC13170467

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.