Evidence map›Paper›PMID 42019295›Full record

ArticleJACC. Advances2026

Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation.

Julia Baranowska, Andrea Fernandez Valledor, Cathrine M Moeller, Boaz Elad, Adi Hertz, Salwa Rahman, Brian LaBarre, Changhee Lee, Adel T Alnatour, Marco Tagliafierro and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Julia BaranowskaDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Andrea Fernandez ValledorDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Cathrine M MoellerDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Boaz EladDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Adi HertzDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Salwa RahmanDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Brian LaBarreDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Changhee LeeDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Adel T AlnatourDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Marco TagliafierroDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Sophie MellyDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Ilan RichterDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jaya BatraDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Elissa DrigginDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Göran DellgrenDivision of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Dor LotanDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Adil YunisDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Ersilia M DeFilippisDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
David MajureDivision of Cardiology, Advanced Cardiac Care, Weill-Cornell Medical College, New York, New York, USA.
Afsana RahmanDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
David BaeDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Kyung T OhDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Karan WatsDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Justin FriedDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jayant RaikhelkarDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Kevin ClerkinDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Farhana LatifDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Koji TakedaDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Gabriel SayerDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Nir UrielDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: nu2126@cumc.columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrocirculatory dysfunction (MCD) contributes to systemic hypoperfusion and end-organ damage. Prior studies have shown MCD in heart failure (HF), but comparative data across HF severity and heart replacement therapies remain limited.

objectivesWe aimed to assess MCD across the spectrum of advanced HF.

methodsWe prospectively enrolled adults with stable chronic HF, cardiogenic shock (CS), HeartMate 3 (HM3) left ventricular assist device support, heart transplant (HT), and healthy controls (HCs), between August 2023 and December 2024. Sublingual microcirculation was assessed using handheld vital microscopy and GlycoCheck software. Primary outcomes were between-group differences in: vessel density; capillary blood volume; perfused boundary region; capillary blood flow; and microvascular health score.

resultsA total of 376 patients (120 HF, 81 CS, 43 HM3, and 132 HT) and 44 HC were included. The median age was 62 years and one-third were females. Microvascular density was significantly lower in CS and HT vs HF and left ventricular assist device. Flow was higher in HM3 than CS and HT (P = 0.039). CS and HT had lower capillary blood volume than HF (P < 0.01). Perfused boundary region was highest in HT patients. Microvascular health score was significantly lower in all patient cohorts compared to HC (all P < 0.01), with HT also showing lower scores than HM3 (P < 0.001).

conclusionsMCD is variably expressed across the spectrum of HF and its treatments, with particularly severe impairment in patients resuscitated from CS and postheart transplantation. These results suggest that restoration of macrohemodynamics does not equate to microvascular recovery and underscore the need for further investigation into the mechanisms, prognostic significance, and therapeutic targeting of systemic microvascular health in advanced cardiovascular disease.

Indexed as

cardiogenic shockheart failureheart transplantationLVADsublingual microcirculation

Identifiers

PMID42019295
PMCPMC13125161

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.