Evidence map›Paper›PMID 42019320›Full record

ArticleJACC. Basic to translational science2026

LVAD Therapy Improves Metabolic and Inflammatory State in the Heart.

Pauline Mury, Olina Dagher, Pierre-Emmanuel Noly, Anique Ducharme, Shreya Gramolini, Filio Billia, Eric Thorin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pauline MuryMontreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
Olina DagherMontreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Department of Cardiac Sciences, Libin Cardiovascular Institute, Calgary, Alberta, Canada.
Pierre-Emmanuel NolyMontreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Surgery, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
Anique DucharmeMontreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
Shreya GramoliniInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Filio BilliaDivision of Cardiology and Ajmera Transplant Center, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Toronto General Hospital Research Institute, Toronto, Ontario, Canada. Electronic address: phyllis.billia@uhn.ca.
Eric ThorinMontreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Surgery, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Left ventricular assist devices remain a major step forward for end-stage heart failure patients awaiting transplantation. We investigated the molecular basis of the longitudinal effect of left ventricular assist device implantation in both ischemic and nonischemic cardiomyopathy patients. The results revealed a common signature of 13 genes associated with glucocorticoid receptor overexpression pretransplantation, independent of the etiology. Four key molecular hub genes from this signature were highlighted, involved respectively in metabolic plasticity (PDK4), limited inflammation (FKBP5 and ZBTB16), and repair (FOXO3). It shows, however, that these pathways contribute to cardiac homeostasis.

Indexed as

end-stage heart failureglucocorticoid receptor signaling pathwayleft ventricular assist devicemetabolic switchtranscriptomics

Identifiers

PMID42019320
PMCPMC13123381

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.