Evidence map›Paper›PMID 42019922›Full record

ArticleMolecular metabolism2026

The long non-coding RNA landscape of endurance exercise training.

Bernardo Bonilauri, Gregory R Smith, Archana N Raja, David Jimenez-Morales, Abdalla Ahmed, Christopher Jin, Lauren M Sparks, Martin J Walsh, Stephen B Montgomery, MoTrPAC Study Group and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Bernardo BonilauriStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Gregory R SmithDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Archana N RajaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
David Jimenez-MoralesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Abdalla AhmedDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Christopher JinDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Lauren M SparksTranslational Research Institute, AdventHealth Research Institute, Orlando, FL, USA.
Martin J WalshDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Stephen B MontgomeryStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
MoTrPAC Study Group
Sue C BodineOklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Euan A AshleyStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Maléne E LindholmStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address: malenel@stanford.edu.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
PAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STUART C. SEALFON, Martin John Walsh · 2017 to 2026
$18.5M
Animal Studies Investigating Molecular Transducers of Physical ActivityU01AG055135 · NIA · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2017 to 2023
$3.1M
NIA NIH HHS U01 AG055135NIDDK NIH HHS P30 DK036836NIDDK NIH HHS U24 DK112331
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) regulate multiple cellular processes. However, knowledge of the responses and regulatory functions of lncRNAs in physical exercise and training remains limited. As part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we conducted a comprehensive analysis of lncRNA expression patterns in 18 tissues after an 8-week progressive endurance training program in rats. The lncRNA expression pattern was largely tissue-specific. In total, 759 unique lncRNAs were found to be differentially expressed across all tissues, generally displaying lower abundance, shorter transcript length, and reduced GC content compared with protein-coding genes. The most pronounced changes were observed in white and brown adipose tissues, the hypothalamus, and the adrenal gland. In the two skeletal muscle tissues investigated, only two lncRNAs were commonly differentially expressed. White and brown adipose tissues revealed a correlation between upregulated differentially expressed lncRNAs and coding genes associated with immune regulation. We identified substantial sex differences in the lncRNA regulatory landscape in response to exercise training. This comprehensive tissue-specific characterization of exercise-responsive lncRNAs opens new avenues for understanding exercise as molecular medicine and may inform the development of lncRNA-targeted therapeutics that harness the beneficial effects of exercise.

Indexed as

Endurance TrainingPhysical Conditioning, AnimalRNA, Long NoncodingAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsFemaleGene Expression RegulationHypothalamusMaleMuscle, SkeletalPhysical EnduranceRatsRats, Sprague-DawleyRNA, Long NoncodingChromatinEndurance trainingExerciseGene expressionlncRNANon-coding

Identifiers

PMID42019922
PMCPMC13158426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.