Evidence map›Paper›PMID 42020313›Full record

ArticleGenes & development2026

Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids.

Thomas Willott, James G Nicholson, Xinyu Zhang, Yunchen Xiao, Olumide Ogunbiyi, Benjamin Draper, Talisa Mistry, Laura K Donovan, Ashirwad Merve, Nicolae Radu Zabet and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thomas Willott *Brain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom.
James G Nicholson *Brain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom.
Xinyu ZhangBrain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom.
Yunchen XiaoBrain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom.
Olumide OgunbiyiDepartment of Histopathology, Great Ormond Street Hospital for Children National Health Services Foundation Trust, London WC1N 3JH, United Kingdom.
Benjamin DraperUniversity College London Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Talisa MistryDepartment of Histopathology, Great Ormond Street Hospital for Children National Health Services Foundation Trust, London WC1N 3JH, United Kingdom.
Laura K DonovanUniversity College London Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Ashirwad MerveDepartment of Histopathology, Great Ormond Street Hospital for Children National Health Services Foundation Trust, London WC1N 3JH, United Kingdom.
Nicolae Radu ZabetBrain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom.ORCID 0000-0001-9964-6271
Sara Badodi *Brain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom; s.marino@qmul.ac.uk s.badodi@qmul.ac.uk.
Silvia Marino *Brain Tumour Research Centre, Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom; s.marino@qmul.ac.uk s.badodi@qmul.ac.uk.

Funding

Cancer Research UK C23985/A29199
6 · The paper itself

Abstract

Medulloblastoma (MB) groups 3 and 4 arise from human-specific developmental contexts that remain experimentally inaccessible, limiting mechanistic insight into tumor initiation. We generated cerebellar organoids (CbOs) from expanded potential stem cells (EPSCs) and performed integrated single-cell transcriptomic and DNA methylation analyses, revealing discrete human rhombic lip progenitor populations whose developmental programs align with group 3- and group 4-associated lineages. Using c-

Indexed as

Cerebellar NeoplasmsCerebellumMedulloblastomaModels, BiologicalOrganoidsAnimalsCoculture TechniquesDNA MethylationHumansMiceProto-Oncogene Proteins c-mycStem CellsTransforming Growth Factor betaTumor MicroenvironmentProto-Oncogene Proteins c-mycTransforming Growth Factor betacell of origincerebellar developmentcerebellar organoidsmedulloblastoma

Identifiers

PMID42020313
PMCPMC13224868

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.