Evidence map›Paper›PMID 42020719›Full record

ArticleMolecular psychiatry2026

IL-15 receptor alpha deficiency triggers depressive-like behaviors via enhanced microglial synapse pruning.

Yue Tang, Yu Huang, Jing Pan, Chaolan Li, Jie Yang, Xunmin Tan, Kangan Hu, Lu Wen, Peijun Xie, Yuxiang Liu and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yue Tang *Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yu Huang *Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0003-2493-3879
Jing PanDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chaolan LiDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jie YangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xunmin TanDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Kangan HuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lu WenDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Peijun XieDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuxiang LiuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Haotian XuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shixin CaoDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jianping ZhangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0009-0000-2999-2945
Yifan LiDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ping LiuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Minghao YuanDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaodong SongDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jing WuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yi HeBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing, 100069, China.
Ma-Li WongDepartment of Psychiatry and Behavioral Sciences, College of Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0003-1512-3073
Julio LicinioDepartment of Psychiatry and Behavioral Sciences, College of Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA.
Peng ZhengDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. pengzheng_cqmu@yeah.net.ORCID http://orcid.org/0000-0002-9864-6832

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major Depressive Disorder (MDD) is a serious mental illness, and neuroinflammation is increasingly recognized as a contributor to its pathogenesis; however, the underlying cellular and molecular mechanisms remain largely unknown. In this study, we performed single-nucleus RNA sequencing to profile prefrontal cortex transcriptomics in interleukin-15 receptor subunit alpha knockout (Il15ra

Indexed as

DepressionInterleukin-15 Receptor alpha SubunitAnimalsChemokine CX3CL1CX3C Chemokine Receptor 1Disease Models, AnimalMajor Depressive DisorderMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaNeuronal PlasticityNeuronsPrefrontal CortexSignal TransductionChemokine CX3CL1CX3C Chemokine Receptor 1Cx3cl1 protein, mouseCx3cr1 protein, mouseInterleukin-15 Receptor alpha Subunit

Identifiers

PMID42020719

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.