Evidence map›Paper›PMID 42020920›Full record

ArticleGeroScience2026

ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice.

Mary Hager, Christopher Adam, Leanne Mercier, Alexander Voorhees, Michael Lee, Lucas Ball, Jackson Yang, Andrzej Bartke, Richard A Miller, Xinna Li

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary HagerCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Christopher AdamCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Leanne MercierCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Alexander VoorheesCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Michael LeeCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Lucas BallCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Jackson YangCollege of Literature, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Andrzej BartkeDepartment of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, 62794-9628, USA.
Richard A MillerUniversity of Michigan Geriatrics Center, BSRB, 109 Zina Pitcher Place, RoomAnn Arbor, MI, 316048109-2200, USA.
Xinna LiDepartment of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, 62794-9628, USA. xinna@umich.edu.ORCID http://orcid.org/0000-0002-7461-5628

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI Thomas Girke, NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
NIA NIH HHS AG023122NIA NIH HHS AG024824NIA NIH HHS U19 AG023122School of Medicine, Southern Illinois University SIU Geriatrics Research InitiativeSchool of Medicine, Southern Illinois University the Hevolution Foundation
6 · The paper itself

Abstract

De novo lipogenesis (DNL) is a metabolic process by which carbohydrates are converted into fatty acids and used for immediate energy or stored as triglycerides for later use. Increased DNL in brown adipose tissue (BAT) is believed to be a marker of metabolic health, but indicates poor metabolism if upregulated in hepatic tissue. ChREBP is a primary regulator of whole-body DNL and promotes production of key enzymes including fatty acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA desaturase. ChREBP is highly expressed in primary sites of lipogenesis such as the liver, intestines, and adipose tissue. In the liver, ChREBP is associated with aging-related symptoms such as increased insulin resistance and gluconeogenesis. In BAT, ChREBP plays an important role as a regulator of uncoupling protein 1 (UCP1) and DNL. Previous research has linked increased metabolic activity in BAT to increased longevity, but the effects of ChREBP-regulated DNL on aging have not been studied yet. To elucidate this relationship, we analyzed the expression of key enzymes and regulators associated with DNL in the liver and BAT of long-lived mutant mice (Ames, Snell, GHR-KO, Pappa-KO, and PTENOE). We observed a decrease in lipogenic enzymes (FASN and ACC1) and their regulator, ChREBP in the liver of the slow-aging mouse models and a contrasting increase in these same markers in BAT. Tissue-specific modulation of DNL is a shared trait among at least these five varieties of slow-aging mice, and may contribute to the extended longevity of these strains.

Indexed as

Adipose tissueAgingCarbohydrate response element binding protein (ChREBP)De novo lipogenesis (DNL)Inter-organ crosstalkLiverMetabolismSlow-aging mice

Identifiers

PMID42020920

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.