Autoimmune nodopathy and focal segmental glomerulosclerosis mediated by anti-NF186 antibody: a case report and literature review.

Yang Zhang, Naijuan Yao, Jie Yang, Yurong Zou, Ping Zhang, Yunlin Feng

Abstract readCase ReportsReview

In one paragraph

Review in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yang ZhangNephrology Department, Institute of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Naijuan YaoDepartment of Infectious Diseases, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Jie YangDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Yurong ZouNephrology Department, Institute of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Ping ZhangNephrology Department, Institute of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Yunlin FengNephrology Department, Institute of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. fengyunlin@med.uestc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFocal segmental glomerulosclerosis (FSGS) and autoimmune nodopathy (AN) exhibit specific associations with anti-NF186 antibodies, which may act as circulating factors contributing to the development of both conditions. However, these cases are very rare, and the underlying pathogenesis mechanisms remain unclear. CASE PRESENTATION: Here, we report a 63-year-old male patient presented with concurrent FSGS and AN, tested positive for anti-NF186 antibodies. Following the administration of plasma exchange and corticosteroid therapy, both neuropathy and nephropathy exhibited significant improvement. He has achieved a favorable outcome following a seven-month of corticosteroid treatment.

conclusionsThis case highlights that acute onset quadriparesis with respiratory involvement may be observed in concurrent AN and FSGS mediated by anti-NF186 antibodies, suggesting a close association of these symptoms.

Indexed as

AutoantibodiesAutoimmune DiseasesGlomerulosclerosis, Focal SegmentalHumansMaleMiddle AgedAutoantibodiesAutoimmune nodopathyFocal segmental glomerulosclerosisNeurofascin 186

Identifiers

PMID42021186

DOI10.1186/s12883-026-04917-2

PMCPMC13237926

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LicenceCC BY-NC-ND

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