ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[Next-Generation Sequencing-Based Detection of Gene Mutations and Its Association With Clinicopathological Features in Gastric Cancer].
Huiyu Zhong, Tangyuheng Liu, Ling Bai, Jin Li, Mengyuan Song, Juan Zhou, Hao Chen
Abstract readEnglish Abstract
In one paragraphArticle in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
Huiyu Zhong， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.ORCID 0009-0009-2433-0761 Tangyuheng Liu， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.
Ling Bai， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.
Jin Li， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.
Mengyuan Song， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.
Juan Zhou， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.
Hao Chen， （ 610041）Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, Institution of Medical and Engineering Integration for Molecular Diagnosis, West China Hospital, Sichuan University & Sichuan Clinical Research Center for Laboratory Medicine,Chengdu 610041, China.ORCID 0009-0000-6351-7363 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Objective: To analyze the gene mutation profile of Chinese patients with gastric cancer and to explore its correlations with clinicopathological characteristics and prognosis. Methods: Fifty-five patients with gastric cancer were enrolled. Next-generation sequencing was performed to detect mutations in cancer-related genes, microsatellite instability, and tumor mutational burden. The associations of high-frequency mutated genes with clinicopathological features and progression-free survival (PFS) were analyzed. Key findings were validated and ethnic heterogeneity was assessed using The Cancer Genome Atlas stomach adenocarcinoma cohort ( Results: Somatic mutations were identified in 85.45% (47/55) of patients. The most frequently mutated genes were Conclusion: Chinese patients with gastric cancer exhibit a distinct gene mutation profile, and key gene mutations are closely associated with tumor aggressiveness. This multi-cohort validation study indicates ethnic differences in the prognostic value of genes such as
Indexed as
AdenocarcinomaHigh-Throughput Nucleotide SequencingMutationStomach NeoplasmsAdultAgedAntigens, CDCadherinsClass I Phosphatidylinositol 3-KinasesDNA-Binding ProteinsFemaleHumansMaleMicrosatellite InstabilityMiddle AgedNuclear ProteinsAntigens, CDARID1A protein, humanCadherinsCDH1 protein, humanClass I Phosphatidylinositol 3-KinasesDNA-Binding ProteinsLRP1B protein, humanNuclear ProteinsPIK3CA protein, humanReceptors, LDLTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53Gene mutationNext-generation sequencingPrecision medicinePrognosisStomach neoplasms
Identifiers
PMID42021891
PMCPMC13095815
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