ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the association and interaction between multiple organophosphorus pesticide metabolites and insulin resistance in non-diabetic adults. Methods: Based on data from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States from 2003 to 2018, a total of 3395 research subjects were included. After natural logarithmic transformation, multiple linear regression, restricted cubic spline, and quantile-weighted regression models were used to separately evaluate the individual and combined exposure effects of urinary organophosphorus pesticide metabolites on insulin resistance. The analysis focused on exploring the interaction between methyl-type and ethyl-type metabolites. Indicators of insulin resistance included the triglyceride-glucose (TyG) index, triglyceride-glucose-body mass index (TyG-BMI), triglyceride-glucose-waist-to-height ratio (TyG-WHtR), and triglyceride-glucose-waist circumference (TyG-WC). Results: On the natural logarithmic scale, except for dimethylthiophosphate (DMTP), the concentrations of all other organophosphorus pesticide metabolites were positively correlated with TyG-BMI and reached statistical significance ( Conclusion: The intake of organophosphorus pesticides may increase indicators used to assess insulin resistance, raising the risk of insulin resistance. Interactions between metabolites may further worsen this effect.
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