Evidence map›Paper›PMID 42022964›Full record

ReviewRSC advances2026

Empowering women's health with miRNA-integrated nanochemical approaches: from reproductive health to cancer care.

Neda Farzizadeh, Zahra Najmi, Morteza Amoozgar, Mona Aminbeidokhti, Amirali Hariri, Arezoo Khosravi, Siavash Iravani, Ali Zarrabi

Abstract readReview
In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Neda FarzizadehDepartment of Midwifery, School of Nursing and Midwifery, Ardabil University of Medical Sciences Ardabil Iran.
Zahra NajmiGraduate School of Biomedical Sciences, Clinical and Translational Science Department, Tufts Medical Center Boston MA USA zahra.najmi@tuftsmedicine.org.ORCID https://orcid.org/0000-0002-8501-5353
Morteza AmoozgarCEO, March Health Company Concord CA 94521 USA.
Mona AminbeidokhtiDepartment of Pathology, University of California San Francisco San Francisco CA 94143 USA.
Amirali HaririDepartment of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Isfahan 8174673461 Iran.
Arezoo KhosraviDepartment of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University Istanbul 34959 Turkey.
Siavash IravaniIndependent Researcher W Nazar ST, Boostan Ave Isfahan Iran siavashira@gmail.com.ORCID https://orcid.org/0000-0003-3985-7928
Ali ZarrabiDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University Istanbul 34396 Turkey alizarrabi@gmail.com ali.zarrabi@istinye.edu.tr.ORCID https://orcid.org/0000-0003-0391-1769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs), a category of small (18-25 nucleotides) non-coding transcripts that modulate gene expression at the post-transcriptional level, are necessary for regulatory processes in female reproduction, specifically in ovarian function and follicular development. Dysregulation of these miRNAs is implicated in reproductive disorders like PCOS, endometriosis, and gynecological cancers. Nanotechnology in medicine encompasses the study of the properties and uses of nanomaterials to enable the development of more precise therapeutic techniques, including biosensing and diagnostics, targeted medication delivery, and tissue engineering. In this review, the recent advancements in utilizing nano-based technologies accompanied by miRNAs, including polymeric nanostructures, metallic nanoparticles (NPs), extracellular vesicle (EV) mimetics, DNA-based nanostructures, and lipid-based nanostructures, to treat conditions like endometriosis and PCOS or breast, cervical, and ovarian cancers and their limitations are discussed. Despite the reported improvements, clinical translation is hampered by challenges related to long-term stability, scalability, and immune recognition. Future research should focus on improving hybrid nanocarrier systems and miRNA-based precision medicine to improve treatment outcomes for women's health.

Identifiers

PMID42022964
PMCPMC13098323

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.