Evidence map›Paper›PMID 42024100›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old.

Gina M Peloso, Dongyu Wang, Sabrina M Abbruzzese, Joshua C Bis, Seung Hoan Choi, Alexa Beiser, Jan Bressler, Josée Dupuis, Alison E Fohner, Mohsen Ghanbari and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-5355-8636
Dongyu WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-1317-2739
Sabrina M AbbruzzeseDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine University of Washington, Seattle, WA, USA.
Seung Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-2797-3190
Alexa BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0001-8551-7778
Jan BresslerHuman Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Alison E FohnerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4231-3331
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-9476-7143
Richard A GibbsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Nancy Heard-CostaDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia.
Quentin Le GrandUniversity of Bordeaux, INSERM, Bordeaux Population Health research center, UMR1219, Bordeaux, France.ORCID 0000-0002-9299-0747
Oscar L LopezDepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Thomas H MosleyThe Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, MS, USA.
Moeen RiazSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia.ORCID 0000-0001-5858-3788
Aïcha SoumaréUniversity of Bordeaux, INSERM, Bordeaux Population Health research center, UMR1219, Bordeaux, France.
Amber YaqubDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-3579-8054
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine University of Washington, Seattle, WA, USA.
Myriam FornageHuman Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
TOPMed Neurocognitive Working Group, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Sequencing Project
Sudha SeshadriGlenn Biggs Institute for Alzheimer and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Anita L DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-9335-2819

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1M
Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approachesU01AG068221 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DESTEFANO, ANITA L, LIN, HONGHUANG · 2021 to 2024
$2.5M
NHLBI NIH HHS R01 HL172803NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG058589NIA NIH HHS U01 AG068221
6 · The paper itself

Abstract

BackgroundIdentifying genetic variants conferring resilience to Alzheimer's disease and related dementia (ADRD) may hold promise for developing therapeutics.ObjectiveTo determine genetic associations with being dementia-free at age 85 (DF85).MethodsWe examined genetic associations, using whole genome sequencing data, with DF85 in three Trans-Omics for Precision Medicine cohorts and the Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium. We tested common variants individually and aggregation of rare (MAF ≤ 1%) coding and non-coding variants in DF85 participants (n = 3657) against individuals who were not DF85 (n = 20,010). We verified associations using a stricter control set who developed dementia before age 85 (n = 5552).ResultsWe observed an association at

Indexed as

Alzheimer DiseaseDementiaWhole Genome SequencingAged, 80 and overCohort StudiesFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideAlzheimer's diseaseassociation studycommon variantsdementia-freegenetic associationprotective variantsrare variants

Identifiers

PMID42024100
PMCPMC13162269

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.