Evidence map›Paper›PMID 42026014›Full record

ArticleJournal of cachexia, sarcopenia and muscle2026

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

Joe W Chiles, Alison Rocco, Vinodh Srinivasasainagendra, Harry B Rossiter, Richard Casaburi, Anna Thalacker-Mercer, J Michael Wells, Emily S Wan, Edwin K Silverman, Michael H Cho and 14 more

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Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Joe W ChilesDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-9935-6319
Alison RoccoDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Vinodh SrinivasasainagendraDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Harry B RossiterThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Richard CasaburiThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Anna Thalacker-MercerDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Michael WellsDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Emily S WanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington, USA.
Yan GaoJackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA.
George T O'ConnorDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Leslie A LangeDepartment of Biomedical Informatics, University of Colorado-Anschutz, Aurora, Colorado, USA.
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, Virginia, USA.
Ani W ManichaikulDepartment of Genome Sciences, University of Virginia, Charlottesville, Virginia, USA.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, New York, USA.
Victor E OrtegaDivision of Pulmonary Medicine, Department of Medicine, Mayo Clinic, Phoenix, Arizona, USA.
Deborah A MeyersDepartment of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Hemant K TiwariDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Merry-Lynn N McDonaldDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4 - 2024 TASK ORDER75N92023D00012 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI OSBORNE, C KENT · 2023 to 2025
$27.9M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.5M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Understanding the Origins of Early COPDR01HL144718 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CURTIS, JEFFREY LOUIS, HAN, MEILAN K · 2020 to 2024
$11.3M
FRAMINGHAM HEART STUDY (FHS), TASK AREA B - PROTOCOL DEVELOPMENT AND BASIC EXAMINATION75N92025D00012 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LLOYD-JONES, DONALD · 2025 to 2025
$8.9M
Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI YAN, WEI · 2019 to 2024
$7.2M
NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92025D00012NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS L70 HL165665NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL144718NHLBI NIH HHS R01 HL151452NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R01 HL166850NHLBI NIH HHS R01 HL172803NHLBI NIH HHS T32 HL105346NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NICHD NIH HHS P50 HD098593NIDDK NIH HHS R01 DK122767NIEHS NIH HHS HHSN268201600033CNIH HHS 75N90024D00012NIH HHS 75N92023D00012NIH HHS 75N95024D00012NIH HHS 75N98024D00012
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this whole genome sequencing (WGS) analysis to identify genetic risk variants for WL in COPD.

methodsWe studied 16 972 participants from the Trans-Omics for Precision Medicine (TOPMed) Initiative and All of Us Research Program. COPD was diagnosed using spirometry in TOPMed, while diagnosis codes were used in All of Us. WL was defined as WL ≥ 5% or a final body mass index (BMI) < 20 kg/m

resultsTwo single variants were associated with WL in COPD among All of Us participants: one intronic variant in HCN1 in Black/African-American participants (chr5:45271359:TACACAC:T, odds ratio with 95% confidence interval (OR (CI

conclusionsIn the first WGS analysis of WL in COPD, we have identified seven novel loci. Further characterization of these loci will validate our findings and improve our understanding of the molecular pathophysiology of this condition.

Indexed as

Pulmonary Disease, Chronic ObstructiveTranscription FactorsWeight LossWhole Genome SequencingAgedFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsTranscription FactorscachexiaCOPDgenomicswastingweight loss

Identifiers

PMID42026014
PMCPMC13106028

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.