Trial reportThe pharmacogenomics journal2026
A randomized trial to evaluate attitudes regarding pharmacogenomics among pregnant and pediatric populations: design and baseline characteristics.
Alexandra C Sundermann, Salisha E Marryshow Batson, Elizabeth A Jasper, Sarah H Jones, Darlene F Fountain, Michelle Liu, Sudeep D Sunthankar, Digna R Velez Edwards
Abstract readRandomized Controlled Trial
In one paragraphTrial report in The pharmacogenomics journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Alexandra C SundermannDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6790-5539 Salisha E Marryshow BatsonDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Elizabeth A JasperDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah H JonesDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Darlene F FountainThomas P. Graham Jr. Division of Pediatric Cardiology and Center for Pediatric Precision Medicine, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN, USA.
Sudeep D SunthankarThomas P. Graham Jr. Division of Pediatric Cardiology and Center for Pediatric Precision Medicine, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-2687-8204 Digna R Velez EdwardsDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA. digna.r.velez.edwards@vumc.org.ORCID 0000-0001-5293-0056 Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)P50HD106446 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PRINCE Joseph KANNANKERIL, Digna R Velez Edwards · 2021 to 2026
$9.7MBuilding Interdisciplinary Research Careers in Women's HealthK12AR084232 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AMY S MAJOR, Digna R Velez Edwards · 2023 to 2026
$1.3MTransdisciplinary approaches for maternal-child health: a focus on gestational weight gainK01DK140644 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Elizabeth A Jasper · 2025 to 2026
$285kEunice Kennedy Shriver National Institute of Child Health and Human Development 5P50HD106446-04Eunice Kennedy Shriver National Institute of Child Health and Human Development 5UL1TR002243-03NCATS NIH HHS UL1 TR002243NIAMS NIH HHS K12 AR084232NICHD NIH HHS P50 HD106446NIDDK NIH HHS K01 DK140644U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K12AR084232U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 1K01DK140644
6 · The paper itselfAbstract
Pharmacogenomics (PGx) is a key component of precision medicine, yet most PGx studies exclude pregnant people and children. The VICE (Vanderbilt Integrated Center of Excellence)-MPRINT (Maternal and Pediatric Precision in Therapeutics): Maternal and Pediatric Pharmacogenetics Trial is a single-center, randomized control trial to assess how PGx testing and return of results influence patients' understanding and perceived utility of PGx testing in a pregnancy and pediatric cohort. Pregnant individuals and families or guardians of children with a chronic health condition aged 0-16 were recruited. We assessed participants' knowledge and attitudes regarding PGx testing at baseline and after receiving results with patient-friendly interpretations. Cases received an educational video about PGx testing with return of results. Controls received PGx test results alone. We aimed to determine perspectives regarding PGx in these understudied populations with the goal of promoting research and clinical implementation of PGx for pregnant women and children.
Indexed as
Health Knowledge, Attitudes, PracticePharmacogeneticsPharmacogenomic TestingAdolescentAdultChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalePrecision MedicinePregnancyReturn of Individual Research Results
Identifiers
PMID42026028
PMCPMC13106030
What Socratic holds
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LicenceCC BY
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