Evidence map›Paper›PMID 42026039›Full record

ArticleNature communications2026

HCN1 is a primary HCN Pacemaker Channel in Neurons.

Uta Enke, Andrea Schweinitz, Debanjan Tewari, Christian Sattler, Ralf Schmauder, Christoph Schmidt-Hieber, Klaus Benndorf

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Uta EnkeInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID 0009-0003-1631-3706
Andrea SchweinitzInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.
Debanjan TewariInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.
Christian SattlerInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID 0000-0003-0731-0469
Ralf SchmauderInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID 0000-0002-8441-4264
Christoph Schmidt-HieberInstitut für Physiologie I, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID 0000-0002-5328-9704
Klaus BenndorfInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany. Klaus.Benndorf@med.uni-jena.de.ORCID 0000-0002-0707-4083

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) RU 2518 P02
6 · The paper itself

Abstract

Rhythmic activity of specialized pacemaker neurons in the brain is necessary to control alertness and circadian timing. Four HCN channels have been identified to generate the pacemaker current I

Indexed as

Biological ClocksCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeuronsPotassium ChannelsAction PotentialsAnimalsHumansIon Channel GatingPatch-Clamp TechniquesCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium Channels

Identifiers

PMID42026039
PMCPMC13106851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.