Evidence map›Paper›PMID 42026388›Full record

ArticleClinical rheumatology2026

Circ_0001185 as a novel therapeutic target for lupus nephritis according to ceRNA network comprehensive analysis.

Siwen Gong, Chongyao Wang, Gainetdinova Emiliia, Yuting Fu, Xiaotong Ding, Wenya He, Lei Zhang, Ruichan Liu, Xingzhi Wang, Yushi Bao and 1 more

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Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Siwen Gong *Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Chongyao Wang *Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Gainetdinova Emiliia *Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Yuting FuDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Xiaotong DingDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Wenya HeDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Lei ZhangDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Ruichan LiuDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Xingzhi WangDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Yushi BaoDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China.
Manshu SuiDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China. suimanshu@163.com.ORCID http://orcid.org/0000-0003-2574-6442

Funding

Hubei Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province CXPJJH122003-28
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the regulatory role of circular RNAs (circRNAs) in lupus nephritis (LN) and to explore their potential mechanisms.

methodsRenal tissue circRNA, miRNA, and mRNA expression profiles were obtained from GEO datasets. Differentially expressed RNAs were analyzed using R software to construct a circRNA-miRNA-mRNA network. Functional enrichment analysis was performed. Correlations between key gene expression and clinical features were analyzed using the Nephroseq V5 database and validated by immunohistochemistry in an independent LN cohort. CIBERSORT was used to explore immune cell infiltration and analyze the correlations between key genes and immune cell types.

resultsBased on the predicted correlations among differentially expressed circRNAs, miRNAs, and mRNAs, a ceRNA network was constructed. Among the six circRNAs with multiple miRNA binding sites, circ_0001185, which is derived from the IFNGR2 gene, was predicted to act as a sponge for miR-30b-5p. In the network, miR-30b-5p, miR-33a-3p, and miR-103a-2-5p exhibited the highest node degrees. And NFAT5 was identified as a common downstream target of both miR-30b-5p and miR-103a-2-5p. Analysis of the Nephroseq V5 dataset revealed that elevated expression of IFNGR2 and NFAT5 in renal tissue was negatively correlated with eGFR. Immunohistochemistry showed increased NFAT5 expression in renal tissues of LN patients, particularly in proliferative LN, and which was positively correlation with neutrophil infiltration. Furthermore, activated dendritic cells and naive CD4 + T cells showed a positive correlation in CIBERSORT analysis.

conclusionThis study constructed a circRNA-miRNA-mRNA ceRNA network and identified a potential circ_0001185/miR-30b-5p/NFAT5 regulatory axis in LN. Bioinformatic analysis suggested that circ_0001185 may have peptide-coding potential, a preliminary observation that warrants further exploration. Together, these findings identify circ_0001185 as a candidate for future functional studies to evaluate its therapeutic potential. Key Points • This study identifies a potential circ_0001185/miR-30b-5p/NFAT5 regulatory axis in LN, which may be associated with Th17 cell differentiation. IFNGR2 and NFAT5 are associated with eGFR, and bioinformatic analysis raises the possibility that circ_0001185 may have peptide-coding potential, suggesting it warrants further exploration as a candidate for therapeutic investigation.

Indexed as

Lupus NephritisRNA, CircularFemaleGene Expression ProfilingGene Regulatory NetworksHumansKidneyMicroRNAsRNA, Competitive EndogenousRNA, MessengerMicroRNAsRNA, CircularRNA, Competitive EndogenousRNA, MessengerComputational biologyLupus nephritisMessenger RNAMiroRNARNA, Ci9rcular

Identifiers

PMID42026388

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.