ArticleWorld journal of surgical oncology2026
Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.
Article in World journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomotic leakage (AL) is a serious complication after colorectal cancer (CRC) surgery. Preoperative insulin resistance (IR) may impair anastomotic healing, but there is limited evidence regarding currently available surrogate markers of IR.
methodsIn this multicenter retrospective cohort study conducted across three tertiary institutions between 2019 and 2024, 1,026 patients who underwent CRC resection with primary anastomosis were analyzed, of whom 128 (12.5%) developed AL. Preoperative IR was assessed with the use of the homeostasis model assessment of insulin resistance (HOMA-IR) and the triglyceride-glucose (TyG) index. The associations were evaluated using multivariable logistic regression adjusting for demographic, clinical, tumor-related, operative, and laboratory covariates. The TyG index cut-off was derived using receiver operating characteristic (ROC) analysis and internally validated using bootstrap resampling and cross-validation.
resultsPatients with AL had higher fasting insulin and HOMA-IR, and IR was more common in the AL group (60.9% vs. 31.1%). The TyG index was also higher in patients with AL, and TyG index ≥ 8.51 was more frequent in the AL group (63.3% vs. 45.5%). In multivariable logistic regression, HOMA-IR ≥ 2.5 (OR 2.95, 95% CI 1.75–4.16) and TyG index ≥ 8.51 (OR 1.58, 95% CI 1.08–2.09) remained independently associated with AL after adjustment for relevant demographic, tumor-related, operative, and laboratory covariates.
conclusionsPreoperative HOMA-IR and TyG index were associated with an increased risk of AL after CRC resection. Further prospective and externally validated studies are needed before routine clinical application can be considered.
trial registrationRetrospectively registered.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.