ArticleCancer medicine2026
Insect Olfactory Receptor-Expressing Sensor Cells for Colorectal Cancer Diagnosis Using Urine Samples.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Current cancer detection methods are hindered by invasiveness and limited sensitivity. In this study, we present a novel diagnostic approach that uses sensor cells expressing insect-derived olfactory receptors (ORs), which respond to volatile organic compounds (VOCs) in urine samples. The response of these sensor cells to urinary VOCs is detected via luminescence emission, generating time-series luminescence data. We screened a library of 483 ORs to identify CRC-discriminative ORs, using urine samples collected from 75 CRC patients and 75 non-cancer controls. After identifying the ORs that could distinguish between urine from CRC patients and urine from non-cancer controls, we applied machine learning to analyze the time-series luminescence data, enabling the creation of a diagnostic model with 80% sensitivity and an ROC-AUC of 0.84. This study demonstrates the potential of OR-based biosensors as noninvasive liquid biopsy tools for CRC diagnosis.
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