Evidence map›Paper›PMID 42027048›Full record

ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2026

Transcriptome screening and functional validation of FN1 in the regulation of granulosa cell proliferation in polycystic ovary syndrome.

Kan Zhou, Wenquan Han, Qijie Wang, Yu Zhang, Jiao Wang

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Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kan ZhouDepartment of Reproductive Medicine, The First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.ORCID https://orcid.org/0009-0006-2980-9104
Wenquan HanReproductive Center, Yili Kazak Autonomous Prefecture Maternal and Child Health Hospital, Yining 835000, Xinjiang, China.
Qijie WangReproductive Center, Yili Kazak Autonomous Prefecture Maternal and Child Health Hospital, Yining 835000, Xinjiang, China.
Yu ZhangDepartment of Reproductive Medicine, The First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.
Jiao WangDepartment of Reproductive Medicine, The First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) affects 11%-13% of reproductive-age women worldwide and is pathologically associated with granulosa cell dysfunction. This study employed transcriptome sequencing of granulosa cells from PCOS patients and non-PCOS controls, followed by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis. Key differentially expressed genes were validated by quantitative real-time PCR. Transcriptome analysis identified 157 upregulated and 71 downregulated mRNAs in PCOS granulosa cells, with enrichment in PI3K-Akt, MAPK, and TGF-beta signaling pathways. Six genes-NPTX2, FN1, CCN1, IDH1, ZCCHC17, and CREG1-were confirmed by qRT-PCR. Protein-protein interaction network analysis identified FN1 as a central hub gene. FN1 knockdown in KGN cells suppressed proliferation, induced apoptosis, and caused G1 phase arrest, accompanied by reduced Akt phosphorylation and altered expression of cyclin D1, p21, and p27. These findings suggest a potential association between FN1 and granulosa cell proliferative dysregulation in PCOS, warranting validation in primary cells and

Indexed as

Cell cycleCell proliferationFibronectin 1 (FN1)Granulosa cellsPolycystic ovary syndromeTranscriptome sequencing

Identifiers

PMID42027048
PMCPMC13527577

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.