In one paragraphArticle in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Chiara PighiClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0001-6163-0135 Nicole ColantoniClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0009-0007-7122-1766 Elena MorrocchiClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0002-3243-9291 Giuseppe Rubens PascucciClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0002-5978-1193 Beatrice RivaltaClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0003-2199-289X Gioacchino Andrea RotuloClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0002-6926-0877 Chiara RossettiClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0001-8200-8724 Veronica SantilliClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0003-1329-6827 Paola ZangariClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0003-0892-6222 Emma Concetta MannoClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0009-0009-0095-8167 Marco SannaClinical Immunology and Vaccinology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0001-5709-5782 Maria Pia CicalesePediatric Immunohematology Unit and BMT Program and San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0003-0371-3279 Sabina CenciarelliPediatric Immunohematology Unit and BMT Program and San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0002-1413-4371 Emilia CirilloDepartment of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.ORCID 0000-0002-0605-649X Giuliana GiardinoDepartment of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.ORCID 0000-0002-0621-9527 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Individuals with inborn errors of immunity often mount suboptimal responses to vaccination, yet the molecular determinants underlying their variable responses to mRNA vaccines remain poorly defined. The present study aimed to identify baseline immune transcriptional signatures predictive of humoral responses to the BNT162b2 (Comirnaty) mRNA vaccine in individuals with inborn errors of immunity. Twenty-one SARS-CoV-2-naïve participants with diverse inborn errors of immunity were stratified as high or low responders to the BNT162b2 vaccine based on anti-SARS-CoV-2 spike IgG titers at day 28 post-vaccination. Although vaccine-induced T cell responses were broadly comparable, low responders had significantly lower frequencies of switched memory B cells (
Indexed as
BNT162 VaccineCOVID-19COVID-19 VaccinesSARS-CoV-2Antibodies, ViralChildChild, PreschoolFemaleGene Expression ProfilingHumansImmunity, HumoralImmunoglobulin GImmunologic MemoryMaleMemory B CellsVaccinationAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunoglobulin Gantibody responseBNT162b2COVID-19Inborn errors of immunitymemory B cellsmRNA vaccineT follicular helper cellstranscriptional profilingvaccine response biomarkers
Identifiers
PMID42027105
PMCPMC13114128
What Socratic holds
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