Evidence map›Paper›PMID 42027121›Full record

ArticleJournal of neurochemistry2026

Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [

Ying-Hwey Nai, Lin Qiu, Hao Jiang, Hong Chen, Abraham Z Snyder, John J Lee, Dean F Wong, Tianyu Huang, Robert Gropler, Tammie L S Benzinger and 2 more

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ying-Hwey NaiMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-6634-8785
Lin QiuMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-8823-4132
Hao JiangMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-8845-4378
Hong ChenMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.
Abraham Z SnyderMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.
John J LeeMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-2269-6267
Dean F WongMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-9343-8367
Tianyu HuangMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-5607-4901
Robert GroplerMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-6550-0570
Tammie L S BenzingerMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-8114-0552
Joel S PerlmutterMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-3263-8917
Zhude TuMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-0325-835X

Funding

Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1M
Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
American Parkinson Disease AssociationBarnes-Jewish Hospital FoundationMcDonnell Center for Systems Neuroscience at Washington UniversityMissouri Chapter of the APDANIBIB NIH HHS EB025815NIBIB NIH HHS P41 EB025815NIH HHS NS0103957NIH HHS NS075321NIH HHS NS075527NIH HHS NS103957NIH HHS NS103988NIH HHS NS107281NIH HHS NS107281-03S1NIH HHS NS134586NIH HHS U19 NS110456NIH HHS U54NS116025NIMH NIH HHS GR0014244NIMH NIH HHS R21 MH092797NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS124789NINDS NIH HHS R01 NS134586NINDS NIH HHS RF1 NS075321NINDS NIH HHS U19 NS110456NINDS NIH HHS U54 NS116025Paula & Roger Riney Fund
6 · The paper itself

Abstract

Sphingosine-1-phosphate receptors (S1PRs) play an important regulatory role in various biological processes, including immune responses and neurodegeneration. We report the binding specificity of an S1PR1 PET radiotracer, [

Indexed as

BrainFluorine RadioisotopesRadiopharmaceuticalsSphingosine-1-Phosphate ReceptorsAnimalsHumansKineticsMalePositron-Emission TomographyRatsFluorine RadioisotopesRadiopharmaceuticalsSphingosine-1-Phosphate Receptorsarterial input function (AIF)kinetic modelingnonhuman primate (NHP)positron emission tomography (PET)sphingosine‐1‐phosphate receptor 1 (S1PR1)

Identifiers

PMID42027121
PMCPMC13244572

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.