Risk factors for venous thromboembolism in sickle cell disease.

Neha Bhasin, Li Zhang, Ayotola Ajayi, Seva Patel, Taylor Imai, Shreya Agarwal

Abstract read

In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Neha BhasinDepartment of Pediatrics, University of California San Francisco, Oakland, California, USA.

Li ZhangDepartment of Medicine, University of California San Francisco, Oakland, California, USA.

Ayotola AjayiDepartment of Pediatrics, University of California San Francisco, Oakland, California, USA.

Seva PatelDepartment of Pediatrics, University of California San Francisco, Oakland, California, USA.

Taylor ImaiDepartment of Pediatrics, University of California San Francisco, Oakland, California, USA.

Shreya AgarwalDepartment of Pediatrics, University of California San Francisco, Oakland, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Individuals with sickle cell disease (SCD) have a high risk for venous thromboembolism (VTE). Objectives: To determine the associated risk factors and recurrence rate of VTE in SCD. Methods: We performed a retrospective review of 719 individuals with SCD followed at our institution between 2013 and 2023 and compared those who developed VTE with those who did not. Results: Of the 719 patients reviewed, 64 (8.9%) patients had 71 VTEs during the study period; 28% of the VTE events were pulmonary embolism and 61% were deep vein thrombosis. The odds ratio (OR) for developing a VTE was 164 ( Conclusion: We conclude that the risk of VTE in SCD is associated with a history of VTE or stroke, increased health care utilization, use of CVCs, hormonal therapies, and smoking. The high VTE recurrence rate in this study suggests a need to better prevent and treat VTEs in individuals with SCD.

Indexed as

Anemia, Sickle CellPulmonary EmbolismVenous ThromboembolismVenous ThrombosisAdolescentAdultFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesRisk FactorsSmokingStrokeYoung Adultcentral venous catheterdeep vein thrombosispulmonary embolismsickle cell diseasevenous thromboembolism

Identifiers

PMID42027307

DOI10.1016/j.rpth.2026.103454

PMCPMC13099461

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