Evidence map›Paper›PMID 42027659›Full record

ArticleF&S reports2026

Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines.

May Shaaban, Jeanna T Ryan, Emmanual Adediran, Leslie V Farland, Anna Z Pollack, C Matthew Peterson, Kathryn M Rexrode, Rachael Hemmert, Madeline Paulsen, Benjamin H Brown and 3 more

Abstract read
In one paragraph

Article in F&S reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

May ShaabanSchool of Medicine, University of Utah, Salt Lake City, Utah.
Jeanna T RyanDivision of Physician Assistant Education and Sciences, University of Utah, Salt Lake City, Utah.
Emmanual AdediranDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Leslie V FarlandDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.
Anna Z PollackDepartment of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia.
C Matthew PetersonDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.
Kathryn M RexrodeDivision of Women's Health, Department of Medicine, Brigham and Women's Health Care Center, Chestnut Hill, Massachusetts.
Rachael HemmertDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Madeline PaulsenDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Benjamin H BrownDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Saskia T SpiessDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Michael W VarnerDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.
Karen C SchliepDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.

Funding

Endometriosis Diagnosis and Subtypes, Reproductive History, and Cardiovascular DiseaseR01HL164715 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Leslie V Farland, Karen C. Schliep · 2023 to 2026
$3.0M
NHLBI NIH HHS R01 HL164715
6 · The paper itself

Abstract

Objective: To study whether incident endometriosis diagnosis, staging, and typology are associated with concurrent elevated serum inflammatory markers interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF- Design: Cross-sectional analysis using data from the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) study. Subjects: A total of 395 premenopausal females in Utah, with no prior endometriosis diagnosis, participating in diagnostic or therapeutic gynecologic laparoscopy/laparotomy, 2007-2009. Exposure: Endometriosis diagnosis, staging (minimal, mild, moderate, severe), and typology (superficial endometriosis [SE], deep infiltrating endometriosis [DE], ovarian endometrioma [OE]), determined through postoperative reports and the revised American Society for Reproductive Medicine classification. Main Outcome Measure: Elevated serum cytokine concentrations defined as IL-6 ≥2 pg/mL, IL-8 ≥3 pg/mL, and TNF-α ≥7.5 pg/mL. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using generalized linear models controlling for age, body mass index (BMI), race/ethnicity, serum cotinine, and reported use of oral hormonal contraception within the past 2 years. Results: Participants were on average 33 years at time of gynecologic laparoscopy/laparotomy, non-Hispanic white (79%), married (75%), with a BMI of 18.5-24.9 kg/m Conclusion: This study found no associations between incident endometriosis diagnosis, staging, typology, and concurrent serum inflammatory markers IL-6, IL-8, and TNF-

Indexed as

cytokinesendometriosis stagingendometriosis typologyepidemiologyInflammatory biomarkers

Identifiers

PMID42027659
PMCPMC13100837

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.