ArticleJAAD international2026
Effects of urbanization-related environmental exposures on atopic dermatitis: A UK Biobank prospective cohort study stratified by genetic risk.
Article in JAAD international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: Atopic dermatitis (AD) arises from complex gene-environmental interactions, and urban exposures are increasingly linked to its pathogenesis. Objective: To investigate the independent and interactive effects of urbanization-related exposures (air pollution, noise, traffic, green space) on AD incidence stratified by genetic susceptibility. Methods: Within the prospective UK Biobank cohort ( Results: Moderate and high air pollution mixtures were significantly associated with a higher AD risk, showing dose-dependent relationships. Higher green space coverage was associated with lower AD risk, particularly in the high genetic risk group (hazard ratio: 0.609, 95% confidence interval: 0.479-0.774). Noise was linked to an elevated AD risk exclusively in high genetic susceptibility, while urban residence and traffic load were associated with increased AD risk irrespective of genetic background. In a mutually adjusted multivariable model, the effects of traffic load and noise were attenuated. Limitations: Restricted ancestry, indoor pollutants, and residential mobility. Conclusion: Urban exposures show dose-dependent associations with AD risk. The assessment of urbanization exposure, in addition to genetic profiling, may represent a practical approach for population-level AD risk assessment and prevention.
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