ArticleBioMed research international2026
The Antioxidant Activity of a Prepared Cream Containing Saffron Extract and Grape Seed Extract.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Antioxidant Activity of a Prepared Cream Containing Saffron Extract and Grape Seed Extract.BioMed research international · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
This study evaluates the antioxidant activity of a topical water-in-oil cream formulated with saffron (Crocus sativus) and grape seed (Vitis vinifera) extracts and characterizes its physicochemical properties. HPLC profiling confirmed that grape seed extract was rich in catechins (26.7%), epicatechins (21.9%), and procyanidins B1 and B2 (13.6% and 9.5%), while saffron extract contained high levels of trans-4-GG-crocin (28.4%), trans-2-gg-crocin (23.5%), and picrocrocin (13.4%). In vitro assays using human lymphocyte cultures demonstrated that saffron extract (2.5%) reduced fast-flash chemiluminescence from 36.1 × 104 to 14.3 × 104, while grape seed extract (5.0%) decreased the same parameter to 16.3 × 104. Light-sum ROS output similarly declined by 39%-50% across extract concentrations. Gene expression analysis revealed significant upregulation of SOD1, NFE2L2, and JUN, indicating activation of endogenous antioxidant pathways. The final cream formulation, containing 2.5% saffron and 5.0% grape seed extract, exhibited a stable pH of 5.9, viscosity of 31,869 cP, and spreadability of 24.32 g/cm
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Registered trials
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