Evidence map›Paper›PMID 42030224›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026

Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.

Daria M Konovalova, Madison D Cooper, Shuli Huang, Danielle X Shane, Jordyn S Mulhern, Ying Ann Chiao, Sarah Y Yuan, Yonggang Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daria M KonovalovaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Madison D CooperDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.ORCID 0009-0003-4887-4110
Shuli HuangDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Danielle X ShaneDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Jordyn S MulhernDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Ying Ann ChiaoAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-1256-4335
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Yonggang MaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.ORCID 0000-0003-1711-0639

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
T Lymphopenia in Ischemic Heart FailureR01HL164446 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Yonggang Ma · 2022 to 2026
$2.0M
Endothelial glycocalyx shedding in septic injuryR01GM142110 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI WU, MACK H, YUAN, SARAH Y · 2022 to 2025
$1.9M
Training in Research on Vascular Inflammation and InjuryT32HL160529 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2022 to 2026
$1.1M
HHS | National Institutes of Health (NIH) GM142110HHS | National Institutes of Health (NIH) HL150732HHS | National Institutes of Health (NIH) HL164446NHLBI NIH HHS R01 HL164446NHLBI NIH HHS R35 HL150732NHLBI NIH HHS T32 HL160529NIGMS NIH HHS R01 GM142110
6 · The paper itself

Abstract

Aging increases susceptibility to a wide range of diseases, partially due to alterations in T lymphocytes. This study aimed to characterize age-related changes in T-cell output, phenotype, and function under basal conditions and after myocardial infarction (MI). Compared with young mice (2-6 mo), aged mice (≥18 mo) demonstrated reduced thymic size and fewer developing thymocytes. Accordingly, circulating T-cell counts were significantly lower in aged mice than in young mice. Interestingly, the spleen and bone marrow of aged mice showed increased T-cell accumulation, primarily due to expansion of memory T cells. Similarly, older humans (≥60 yr old) exhibited reduced circulating T cells and a higher proportion of memory T cells. Under basal conditions, aged splenic T cells expressed higher mRNA levels of proinflammatory and cytotoxic factors (e.g.,

Indexed as

AgingMemory T CellsMyocardial InfarctionRegenerationThymus GlandT-LymphocytesAge FactorsAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLPhenotypeT-Cell ExhaustionThymocytesagingbone marrowmyocardial infarctionT cellsthymus

Identifiers

PMID42030224
PMCPMC13225476

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.